Exhaled Nitric Oxide Correlates with Airway Hyperresponsiveness in Steroid-naive Patients with Mild Asthma

• Published in: American journal of respiratory and critical care medicine Vol. 157; no. 3; pp. 894 - 898
• Main Authors: DUPONT, LIEVEN J, ROCHETTE, FELICIEN, DEMEDTS, MAURITS G, VERLEDEN, GEERT M
• Format: Journal Article
• Language: English
• Published: New York, NY Am Thoracic Soc 01.03.1998; American Lung Association
• Subjects: Adrenergic beta-Agonists - administration & dosage; Adrenergic beta-Agonists - therapeutic use; Adult; Airway Obstruction - metabolism; Airway Obstruction - physiopathology; Anti-Asthmatic Agents - administration & dosage; Anti-Asthmatic Agents - therapeutic use; Anti-Inflammatory Agents - administration & dosage; Anti-Inflammatory Agents - therapeutic use; Asthma - drug therapy; Asthma - metabolism; Asthma - physiopathology; Beclomethasone - administration & dosage; Beclomethasone - therapeutic use; Biological and medical sciences; Biomarkers - analysis; Bronchial Hyperreactivity - metabolism; Bronchial Hyperreactivity - physiopathology; Bronchial Provocation Tests; Chronic Disease; Chronic obstructive pulmonary disease, asthma; Cough - metabolism; Cough - physiopathology; Dyspnea - metabolism; Dyspnea - physiopathology; Female; Forced Expiratory Volume - drug effects; Glucocorticoids - administration & dosage; Glucocorticoids - therapeutic use; Histamine - administration & dosage; Humans; Male; Medical sciences; Nitric Oxide - analysis; Nitric Oxide - metabolism; Pneumology; Respiration; Respiratory Sounds - physiology; Human; Expired air; Corticosteroid; Hyperreactivity; Respiratory disease; Antiinflammatory agent; Bronchus; Exploration; Endogenous substance; Concentration; Asthma; Dose activity relation; Induced bronchoconstriction; Histamine; Chemotherapy; Relation; Treatment; Obstructive pulmonary disease; Nitrogen Oxides; Comparative study

Endogenously released nitric oxide (NO) has been detected in the exhaled air of humans. Exhaled NO (NOexh) levels have been significantly increased in patients with inflammatory airways disorders such as asthma, and NOexh has been suggested to be a usable marker of airway inflammation. In the presen...