Sulindac Inhibits Activation of the NF-κB Pathway

• Published in: The Journal of biological chemistry Vol. 274; no. 38; pp. 27307 - 27314
• Main Authors: Yamamoto, Yumi, Yin, Min-Jean, Lin, Keng-Mean, Gaynor, Richard B.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 17.09.1999
• Subjects: IB kinase; IKKb protein; NF-B protein; prostaglandins; sulindac sulfide; sulindac sulfone

Sulindac is a non-steroidal anti-inflammatory agent that is related both structurally and pharmacologically to indomethacin. In addition to its anti-inflammatory properties, sulindac has been demonstrated to have a role in the prevention of colon cancer. Both its growth inhibitory and anti-inflammat...