Analyzing repeated measures semi-continuous data, with application to an alcohol dependence study

• Published in: Statistical methods in medical research Vol. 25; no. 1; p. 133
• Main Authors: Liu, Lei, Strawderman, Robert L, Johnson, Bankole A, O'Quigley, John M
• Format: Journal Article
• Language: English
• Published: England 01.02.2016
• Subjects: Alcohol Deterrents - therapeutic use; Alcoholism - drug therapy; Biostatistics; Data Interpretation, Statistical; Fructose - analogs & derivatives; Fructose - therapeutic use; Humans; Likelihood Functions; Linear Models; Models, Statistical; Proportional Hazards Models; Randomized Controlled Trials as Topic - statistics & numerical data; Hierarchical model; longitudinal data analysis; non-nested model; mixed model; model comparison; generalized linear mixed model

Two-part random effects models (Olsen and Schafer,(1) Tooze et al.(2)) have been applied to repeated measures of semi-continuous data, characterized by a mixture of a substantial proportion of zero values and a skewed distribution of positive values. In the original formulation of this model, the na...