Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation
A small-molecule compound binds to the RGS domain of axin, promotes the degradation of β-catenin and Ras through the GSK3β-mediated destruction complex, and reduces the growth of KRAS and APC mutant colorectal cancer cell lines. Both the Wnt/β-catenin and Ras pathways are aberrantly activated in mos...
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Published in | Nature chemical biology Vol. 12; no. 8; pp. 593 - 600 |
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Main Authors | , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
New York
Nature Publishing Group US
01.08.2016
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Subjects | |
Online Access | Get full text |
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