RGS2 promotes the translation of stress-associated proteins ATF4 and CHOP via its eIF2B-inhibitory domain

• Published in: Cellular signalling Vol. 59; pp. 163 - 170
• Main Authors: Wang, Chang-Hui (Jenny), Chidiac, Peter
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.07.2019
• Subjects: ATF4; Cell stress response; CHOP; Eukaryotic initiation factor 2 (eIF2); Regulator of G protein signaling 2 (RGS2); Translation; CHOP; Translation; Regulator of G protein signaling 2 (RGS2); Cell stress response; Eukaryotic initiation factor 2 (eIF2); ATF4
• ISSN: 0898-6568; 1873-3913; 1873-3913
• DOI: 10.1016/j.cellsig.2019.02.007

Regulator of G protein signaling 2 (RGS2) is upregulated by multiple forms of stress and can augment translational attenuation associated with the phosphorylation of the initiation factor eIF2, a hallmark of several stress-induced coping mechanisms. Under stress-induced translational inhibition, key...