An Improved DNA Vaccine Against Bovine Herpesvirus-1 Using CD40L and a Chemical Adjuvant Induces Specific Cytotoxicity in Mice

• Published in: Viral immunology Vol. 34; no. 2; p. 68
• Main Authors: Langellotti, Cecilia A, Gammella, Mariela, Soria, Ivana, Bellusci, Carolina, Quattrocchi, Valeria, Vermeulen, Monica, Mongini, Claudia, Zamorano, Patricia I
• Format: Journal Article
• Language: English
• Published: United States 01.03.2021
• Subjects: Adjuvants, Immunologic; Animals; Antibodies, Viral; Cattle; CD40 Ligand - genetics; Herpesvirus 1, Bovine - genetics; Mice; Vaccines, DNA; CD40L; mice model; BoHV-1 DNA vaccine; chemical adjuvants; cytotoxic response

Bovine herpesvirus-1 (BoHV-1) uses many mechanisms to elude the immune system; one of them is spreading intracellularly, even in the presence of specific antiviral antibodies. Cytotoxic T lymphocytes (CTLs) are necessary to eliminate the virus. The main preventive strategy is vaccination based on in...