Oxidative modulation of K+ channels in the central nervous system in neurodegenerative diseases and aging

• Published in: Antioxidants & redox signaling Vol. 22; no. 6; p. 505
• Main Authors: Peers, Chris, Boyle, John P
• Format: Journal Article
• Language: English
• Published: United States 20.02.2015
• Subjects: Aging - metabolism; Animals; Apoptosis; Carbon Monoxide - metabolism; Central Nervous System - metabolism; Gasotransmitters - metabolism; Humans; Hydrogen Sulfide - metabolism; Neurodegenerative Diseases - metabolism; Oxidation-Reduction; Oxidative Stress; Potassium Channels - metabolism; Reactive Oxygen Species - metabolism

Oxidative stress and damage are well-established components of neurodegenerative diseases, contributing to neuronal death during disease progression. Here, we consider key K(+) channels as target proteins that can undergo oxidative modulation, describe what is understood about how this influences di...