Causal relationship between 91 circulating inflammatory proteins and gynecological diseases: A two-sample bidirectional Mendelian randomization study

• Published in: International journal of biological macromolecules Vol. 316; no. Pt 1; p. 144729
• Main Authors: Wang, Jie-Lin, Zhang, Ping-An, Yuan, Jing, Huang, Xiang-Chun, Cheng, Jia-Chen, Bao, Hai-Juan, Li, Jing, Chen, Shuo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2025
• Subjects: Female; Genital Diseases, Female - blood; Genital Diseases, Female - genetics; Gynecological diseases; Humans; Inflammation - blood; Inflammation - genetics; Inflammatory proteins; Interleukin-1alpha - blood; Interleukin-1alpha - genetics; Mendelian randomization; Mendelian Randomization Analysis; Gynecological diseases; Mendelian randomization; Inflammatory proteins

Gynecological diseases pose major public health challenges due to their detrimental impact on women's quality of life and fertility. While growing evidence implicates inflammatory proteins in the pathogenesis of these conditions, their causal roles remain unclear. In this study, we conducted a...