Gα12/13 signaling promotes cervical cancer invasion through the RhoA/ROCK-JNK signaling axis

• Published in: Biochemical and biophysical research communications Vol. 473; no. 4; pp. 1240 - 1246
• Main Authors: Yuan, Bo, Cui, Jinquan, Wang, Wuliang, Deng, Kehong
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 13.05.2016
• Subjects: 60 APPLIED LIFE SCIENCES; Cell Line, Tumor; CELL PROLIFERATION; Cervical cancer; Enzyme Activation; Female; GTP-ASES; GTP-Binding Protein alpha Subunits, G12-G13 - metabolism; GUANINE; Gα12/13; HeLa Cells; Humans; INHIBITION; Invasion; MAP Kinase Signaling System; Neoplasm Invasiveness; NEOPLASMS; NUCLEOTIDES; ONCOGENES; PLANT GROWTH; rho-Associated Kinases - metabolism; rhoA GTP-Binding Protein - metabolism; RhoA/ROCK-JNK; Signal Transduction; SIGNALS; STIMULATION; THROMBIN; TOXINS; TUMOR CELLS; Uterine Cervical Neoplasms - metabolism; Uterine Cervical Neoplasms - pathology; RhoA/ROCK-JNK; Cervical cancer; Gα12/13; Invasion

Several reports have indicated a role for the members of the G12 family of heterotrimeric G proteins (Gα12 and Gα13) in oncogenesis and tumor cell growth. The aims of the present study were to evaluate the role of G12 signaling in cervical cancer. We demonstrated that expression of the G12 proteins...