Protective role of Decylubiquinone against secondary melanoma at lung in B16F10 induced mice by reducing E-cadherin expression and ameliorating ROCKII-Limk1/2-Cofiliin mediated metastasis

• Published in: Cellular signalling Vol. 101; p. 110486
• Main Authors: Chatterjee, Sujan, Patra, Debajyoti, Ghosh, Pujita, Banerjee, Soumi, Mishra, Snehasis, Chakraborty, Pratip, Chowdhury, Kaustav Dutta, Basu, Anupam, Sadhukhan, Gobinda Chandra
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.01.2023
• Subjects: Actins; Animals; Cadherins - metabolism; Cell Line, Tumor; Cell Movement; Decylubiquinone; E-cadherin; Limk1/2-Cofilin-F-actin axis; Lung - metabolism; Lung Neoplasms - metabolism; Melanoma - metabolism; Melanoma, Experimental - pathology; Mesenchymal-epithelial transition; Mice; Mice, Inbred C57BL; Neoplasm Metastasis - pathology; Pulmonary metastatic melanoma; Reactive Oxygen Species; ROCKII; HNF; Pulmonary metastatic melanoma; ROCK; DMSO; E-cadherin; Dub; DMEM; FBS; ID-1; PBS; ROCKII; IL; VEGF; MT; EDTA; BAL; ECM; Decylubiquinone; MMP; NAC; Limk1/2-Cofilin-F-actin axis; TGFβ; LIMK; Smad; Mesenchymal-epithelial transition

Melanoma is one of the most consequential skin cancer with a rising death incidences. Silent but belligerent nature of metastatic sprouting is the leading cause of melanoma related mortality. Invasion of metastatic cells and re-expression of E-Cadherin play the crucial role in the establishment of s...