Exploring the influence of magnesium stearate content and mixing modality on the rheological properties and in vitro aerosolization of dry powder inhaler

• Published in: International journal of pharmaceutics Vol. 642; p. 123179
• Main Authors: Li, Jiayi, Ma, Sibo, He, Xianhong, Sun, Ying, Zhang, Xin, Guan, Jian, Mao, Shirui
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 25.07.2023
• Subjects: Dry powder inhaler (DPI); In vitro deposition; Magnesium stearate (MgSt); Mixing modality; Rheological properties; Mixing modality; In vitro deposition; Magnesium stearate (MgSt); Dry powder inhaler (DPI); Rheological properties

[Display omitted] Since carrier-based dry powder inhalers (DPIs) suffer from inadequate drug deposition in the lung, an increasing number of marketed products have added magnesium stearate (MgSt) to improve the aerosolization, dispersion, and stability against moisture of DPI. However, for carrier-b...