Fusion performance of low-dose recombinant human bone morphogenetic protein 2 and bone marrow-derived multipotent stromal cells in biodegradable scaffolds: a comparative study in a large animal model of anterior lumbar interbody fusion

• Published in: Spine (Philadelphia, Pa. 1976) Vol. 36; no. 21; p. 1752
• Main Authors: Abbah, Sunny A, Lam, Christopher X F, Ramruttun, Amit K, Goh, James C H, Wong, Hee-Kit
• Format: Journal Article
• Language: English
• Published: United States 01.10.2011
• Subjects: Absorbable Implants; Animals; Biomechanical Phenomena; Bone Morphogenetic Protein 2 - administration & dosage; Calcium Phosphates - chemistry; Cells, Cultured; Humans; Ilium - transplantation; Lumbar Vertebrae - diagnostic imaging; Lumbar Vertebrae - drug effects; Lumbar Vertebrae - pathology; Lumbar Vertebrae - surgery; Male; Mesenchymal Stem Cell Transplantation; Models, Animal; Multipotent Stem Cells - transplantation; Osseointegration - drug effects; Polyesters - chemistry; Range of Motion, Articular; Recombinant Proteins - administration & dosage; Spinal Fusion - methods; Swine; Time Factors; Tissue Engineering - methods; Tissue Scaffolds; Transplantation, Autologous; X-Ray Microtomography

A large animal study comparing interbody fusion of a bioresorbable scaffold loaded with either low-dose recombinant human bone morphogenetic protein 2 (rhBMP-2) or bone marrow-derived multipotent stromal cells (BMSCs). To compare the quality of fusion resulting from implantation of medical grade pol...