Autoantigenicity of DFS70 is restricted to the conformational epitope of C-terminal alpha-helical domain

• Published in: Journal of autoimmunity Vol. 23; no. 3; pp. 221 - 231
• Main Authors: Ogawa, Yasushi, Sugiura, Kazumitsu, Watanabe, Akihiro, Kunimatsu, Mitoshi, Mishima, Masaki, Tomita, Yasushi, Muro, Yoshinao
• Format: Journal Article
• Language: English
• Published: London Elsevier Ltd 01.11.2004; Elsevier
• Subjects: Adaptor Proteins, Signal Transducing; Adolescent; Adult; Aged; Amino Acid Sequence; Animals; Autoantigens - chemistry; Autoantigens - genetics; Autoantigens - immunology; Autoimmunity; Biological and medical sciences; Child; Circular Dichroism; Conformation; DFS70/LEDGF; Epitope; Epitope Mapping; Epitopes - chemistry; Epitopes - genetics; Epitopes - immunology; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; General aspects; Humans; Immune Sera - immunology; Immunopathology; Immunoprecipitation; Male; Medical sciences; Middle Aged; Molecular Sequence Data; Mutation - genetics; Natural autoantibody; Protein Structure, Secondary; Protein Structure, Tertiary; Sequence Alignment; Tissue Donors; Trans-Activators - chemistry; Trans-Activators - genetics; Trans-Activators - immunology; Transcription Factors; Autoimmunity; Epitope; DFS70/LEDGF; Conformation; Natural autoantibody; C terminal-Sequence; Immunopathology; Autoantigen; Immunology; Antigenic determinant; Antibody; Autoantibody

Autoantibodies against DFS70 (Dense Fine Speckles 70) are found in 30% of Japanese atopic dermatitis patients, and less frequently in patients with other diseases. We have recently reported that they are also seen in 11% of hospital workers, but in only ∼2% of patients with systemic rheumatic diseas...