Molecular strategies in Metazoan genomic evolution

During the evolution of Metazoa, the mitochondrial genome has remained practically unchanged as indicated by its small size and constant gene content in each lineage, although several evolutionary processes have taken place. In contrast, the nuclear genome of Metazoa has undergone dramatic changes,...

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Bibliographic Details
Published inGene Vol. 300; no. 1-2; pp. 195 - 201
Main Authors Saccone, Cecilia, Barome, Pierre Olivier, D'Erchia, Anna Maria, D'Errico, Ilenia, Pesole, Graziano, Sbisà, Elisabetta, Tullo, Apollonia
Format Journal Article
LanguageEnglish
Published Netherlands 30.10.2002
Subjects
Alternative Splicing
Animals
Binding Sites - genetics
Cell Nucleus - genetics
DNA, Mitochondrial - genetics
DNA-Binding Proteins - genetics
Evolution, Molecular
Genes - genetics
Genes, Tumor Suppressor
Genome
Humans
Membrane Proteins
Nuclear Proteins - genetics
Phosphoproteins - genetics
Trans-Activators - genetics
Transcription Factors
Tumor Protein p73
Tumor Suppressor Protein p53 - genetics
Tumor Suppressor Proteins
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Summary:During the evolution of Metazoa, the mitochondrial genome has remained practically unchanged as indicated by its small size and constant gene content in each lineage, although several evolutionary processes have taken place. In contrast, the nuclear genome of Metazoa has undergone dramatic changes, as is demonstrated by some entire genomes completely sequenced so far. The expansion of gene families and the appearance of new functions and new regulatory circuits are among the most prominent features. Here, we report a description of the evolution of the p53 gene family as an example of expansion of both genetic complexity and gene expression of the nuclear genome.
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ISSN:0378-1119
DOI:10.1016/s0378-1119(02)01036-3