Progression of insulin resistance: A link between risk factors and the incidence of diabetes
Insulin resistance (IR) changes over time during the development of type 2 diabetes. Some reports showed that obesity was associated with progression of IR. However, no study has explored if change of IR predicts incident diabetes, and no study has investigated other factors associated with the chan...
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| Published in | Diabetes research and clinical practice Vol. 161; p. 108050 |
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| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Ireland
Elsevier B.V
01.03.2020
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| Abstract | Insulin resistance (IR) changes over time during the development of type 2 diabetes. Some reports showed that obesity was associated with progression of IR. However, no study has explored if change of IR predicts incident diabetes, and no study has investigated other factors associated with the change.
In this study, 1184 subjects without diabetes at baseline were enrolled in 2006–2016 with a median follow-up period of 4.5 years. Diabetes was diagnosed by oral glucose tolerance test and hemoglobin A1c, or if anti-diabetic agents were used. HOMA2-IR and ISI0,120 were used to estimate IR.
The annual changes of HOMA2-IR(ΔHOMA2-IR/year) and ISI0,120(ΔISI0,120/year) were associated with BMI, waist circumference(WC), glucose, HbA1c, triglyceride and HDL-cholesterol. Subjects with pre-diabetes or metabolic syndrome were associated with a more rapid increase of IR. ΔHOMA2-IR/year and ΔISI0,120/year were correlated with annual changes of BMI and WC. The hazard ratios for ΔHOMA2-IR/year and ΔISI0,120/year to predict incident diabetes were 1.39 (95% CI 1.22–1.59, p < 0.001) and 0.13 (95% CI 0.09–0.19, p < 0.001) in adjusted models, respectively.
Change of IR can be used as a surrogate marker of incident diabetes. The progression of IR is an important pathophysiologic link between risk factors and the incidence of diabetes. |
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| AbstractList | AIMSInsulin resistance (IR) changes over time during the development of type 2 diabetes. Some reports showed that obesity was associated with progression of IR. However, no study has explored if change of IR predicts incident diabetes, and no study has investigated other factors associated with the change. METHODSIn this study, 1184 subjects without diabetes at baseline were enrolled in 2006-2016 with a median follow-up period of 4.5 years. Diabetes was diagnosed by oral glucose tolerance test and hemoglobin A1c, or if anti-diabetic agents were used. HOMA2-IR and ISI0,120 were used to estimate IR. RESULTSThe annual changes of HOMA2-IR(ΔHOMA2-IR/year) and ISI0,120(ΔISI0,120/year) were associated with BMI, waist circumference(WC), glucose, HbA1c, triglyceride and HDL-cholesterol. Subjects with pre-diabetes or metabolic syndrome were associated with a more rapid increase of IR. ΔHOMA2-IR/year and ΔISI0,120/year were correlated with annual changes of BMI and WC. The hazard ratios for ΔHOMA2-IR/year and ΔISI0,120/year to predict incident diabetes were 1.39 (95% CI 1.22-1.59, p < 0.001) and 0.13 (95% CI 0.09-0.19, p < 0.001) in adjusted models, respectively. CONCLUSIONSChange of IR can be used as a surrogate marker of incident diabetes. The progression of IR is an important pathophysiologic link between risk factors and the incidence of diabetes. Insulin resistance (IR) changes over time during the development of type 2 diabetes. Some reports showed that obesity was associated with progression of IR. However, no study has explored if change of IR predicts incident diabetes, and no study has investigated other factors associated with the change. In this study, 1184 subjects without diabetes at baseline were enrolled in 2006–2016 with a median follow-up period of 4.5 years. Diabetes was diagnosed by oral glucose tolerance test and hemoglobin A1c, or if anti-diabetic agents were used. HOMA2-IR and ISI0,120 were used to estimate IR. The annual changes of HOMA2-IR(ΔHOMA2-IR/year) and ISI0,120(ΔISI0,120/year) were associated with BMI, waist circumference(WC), glucose, HbA1c, triglyceride and HDL-cholesterol. Subjects with pre-diabetes or metabolic syndrome were associated with a more rapid increase of IR. ΔHOMA2-IR/year and ΔISI0,120/year were correlated with annual changes of BMI and WC. The hazard ratios for ΔHOMA2-IR/year and ΔISI0,120/year to predict incident diabetes were 1.39 (95% CI 1.22–1.59, p < 0.001) and 0.13 (95% CI 0.09–0.19, p < 0.001) in adjusted models, respectively. Change of IR can be used as a surrogate marker of incident diabetes. The progression of IR is an important pathophysiologic link between risk factors and the incidence of diabetes. Insulin resistance (IR) changes over time during the development of type 2 diabetes. Some reports showed that obesity was associated with progression of IR. However, no study has explored if change of IR predicts incident diabetes, and no study has investigated other factors associated with the change. In this study, 1184 subjects without diabetes at baseline were enrolled in 2006-2016 with a median follow-up period of 4.5 years. Diabetes was diagnosed by oral glucose tolerance test and hemoglobin A1c, or if anti-diabetic agents were used. HOMA2-IR and ISI were used to estimate IR. The annual changes of HOMA2-IR(ΔHOMA2-IR/year) and ISI (ΔISI /year) were associated with BMI, waist circumference(WC), glucose, HbA1c, triglyceride and HDL-cholesterol. Subjects with pre-diabetes or metabolic syndrome were associated with a more rapid increase of IR. ΔHOMA2-IR/year and ΔISI /year were correlated with annual changes of BMI and WC. The hazard ratios for ΔHOMA2-IR/year and ΔISI /year to predict incident diabetes were 1.39 (95% CI 1.22-1.59, p < 0.001) and 0.13 (95% CI 0.09-0.19, p < 0.001) in adjusted models, respectively. Change of IR can be used as a surrogate marker of incident diabetes. The progression of IR is an important pathophysiologic link between risk factors and the incidence of diabetes. |
| ArticleNumber | 108050 |
| Author | Chen, Szu-Chi Li, Hung-Yuan Chuang, Lee-Ming Hua, Cyue-Huei Lin, Mao-Shin Lin, Chia-Hung Shih, Shyang-Rong Hsein, Yenh-Chen Yang, Chung-Yi Wu, Wan-Chen Fan, Kang-Chih Wei, Jung-Nan |
| Author_xml | – sequence: 1 givenname: Wan-Chen surname: Wu fullname: Wu, Wan-Chen organization: Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan – sequence: 2 givenname: Jung-Nan surname: Wei fullname: Wei, Jung-Nan organization: Chia Nan University of Pharmacy and Science, Tainan, Taiwan – sequence: 3 givenname: Szu-Chi surname: Chen fullname: Chen, Szu-Chi organization: Division of Endocrinology and Metabolism, Department of Internal Medicine, Cardinal Tien Hospital, New Taipei City, Taiwan – sequence: 4 givenname: Kang-Chih surname: Fan fullname: Fan, Kang-Chih organization: Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan – sequence: 5 givenname: Chia-Hung surname: Lin fullname: Lin, Chia-Hung organization: Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan – sequence: 6 givenname: Chung-Yi surname: Yang fullname: Yang, Chung-Yi organization: Department of Medical Imaging, E-Da Hospital, Kaohsiung, Taiwan – sequence: 7 givenname: Mao-Shin surname: Lin fullname: Lin, Mao-Shin organization: Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan – sequence: 8 givenname: Shyang-Rong surname: Shih fullname: Shih, Shyang-Rong organization: Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan – sequence: 9 givenname: Cyue-Huei surname: Hua fullname: Hua, Cyue-Huei organization: Division of Clinical Pathology, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan – sequence: 10 givenname: Yenh-Chen surname: Hsein fullname: Hsein, Yenh-Chen organization: Division of Clinical Pathology, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan – sequence: 11 givenname: Lee-Ming surname: Chuang fullname: Chuang, Lee-Ming organization: Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan – sequence: 12 givenname: Hung-Yuan surname: Li fullname: Li, Hung-Yuan email: larsli@ntuh.gov.tw organization: Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan |
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| Cites_doi | 10.1007/s00125-001-0771-8 10.1210/jc.2004-2479 10.1038/srep43521 10.1007/s11684-013-0262-6 10.1126/science.1104343 10.1210/edrv.21.6.0415 10.1111/j.1440-1681.2011.05596.x 10.1016/j.bbrc.2008.07.068 10.1161/ATVBAHA.113.301397 10.1016/S0140-6736(97)03062-6 10.1016/j.atherosclerosis.2013.12.013 10.1161/01.ATV.20.7.1789 10.1001/jama.2018.19329 10.2337/dc13-2383 10.2337/db12-0207 10.2337/diabetes.48.6.1258 10.1016/j.numecd.2009.06.009 10.2337/dc18-S002 10.1016/S0168-8227(99)00116-3 10.1016/j.diabres.2008.11.031 10.2337/dc12-0607 10.1056/NEJMoa0907295 10.2337/diacare.25.6.995 10.1093/aje/kwg260 10.2337/diacare.26.8.2341 10.1097/MOL.0b013e3283412279 10.1055/s-2002-34788 10.3389/fendo.2013.00052 10.2337/diacare.22.8.1266 10.1186/s12966-016-0424-4 10.1152/ajpendo.00514.2001 10.1590/0004-2730000003223 10.1001/jama.2010.843 10.1161/01.HYP.30.5.1144 10.1371/journal.pmed.1001602 10.1186/s12944-017-0572-9 10.1161/circ.106.25.3143 10.2337/dc07-0360 10.1056/NEJM199109263251307 10.1016/j.cell.2012.02.017 10.2337/dc08-1468 10.1038/nrendo.2011.235 10.2337/diabetes.48.1.150 10.2337/dc14-2770 10.2337/dc12-1452 |
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| Keywords | ISI0,120 Type 2 diabetes mellitus HOMA2-IR Change of Insulin resistance Incidence ISI(0,120) |
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| References | Pihlajamaki, Karjalainen, Karhapaa, Vauhkonen, Taskinen, Deeb (b0195) 2000; 20 Peplies, Bornhorst, Gunther, Fraterman, Russo, Veidebaum (b0030) 2016; 13 Stefan, Schafer, Machicao, Machann, Schick, Claussen (b0200) 2005; 90 Tuomi, Carlsson, Li, Isomaa, Miettinen, Nilsson (b0220) 1999; 48 Petersen, Dufour, Hariri, Nelson-Williams, Foo, Zhang (b0185) 2010; 362 Lakka, Salonen, Tuomilehto, Kaplan, Lakka (b0020) 2002; 34 Hill, Levy, Matthews (b0070) 2013; 36 Gutt, Davis, Spitzer, Llabre, Kumar, Czarnecki (b0075) 2000; 47 Riserus, Arnlov, Berglund (b0080) 2007; 30 American Diabetes A. 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2018. Diabetes care. 2018;41:S13-S27. Takeda, Kawasaki, Shimizu, Konoue, Fujiyama, Murao (b0235) 2002; 25 Steiner, Vranic (b0170) 1982; 6 Chen, Yu, Xiong, Du, Zhu (b0125) 2017; 16 Ma, Yang, Shih, Hsieh, Hung, Chiu (b0055) 2013; 36 Zhou, Xiang, Ji, Jia, Ning, Huang (b0230) 2013; 62 Ye (b0010) 2013; 7 Biggs, Mukamal, Luchsinger, Ix, Carnethon, Newman (b0090) 2010; 303 Lopez-Rios, Perez-Jimenez, Martinez-Quintana, Rodriguez Gonzalez, Diaz-Chico, Novoa (b0205) 2011; 21 McArdle, Finucane, Connaughton, McMorrow, Roche (b0100) 2013; 4 Ye, Gimble (b0115) 2011; 38 Lowell, Shulman (b0135) 2005; 307 Castro, Kolka, Kim, Bergman (b0120) 2014; 58 Chang, Sung, Yun, Jung, Kim, Kwon (b0025) 2013; 8 White (b0110) 2002; 283 Hawa, Buchan, Ola, Wun, DeMicco, Bao (b0225) 2014; 37 Li, Wei, Lin, Smith, Vainio, Lin (b0050) 2009; 404 Lotta, Wittemans, Zuber, Stewart, Sharp, Luan (b0145) 2018; 320 Robciuc, Maranghi, Lahikainen, Rader, Bensadoun, Oorni (b0190) 2013; 33 Radtke, Midthjell, Nilsen, Grill (b0215) 2009; 32 Moller, Flier (b0005) 1991; 325 Vistisen, Witte, Tabak, Herder, Brunner, Kivimaki (b0040) 2014; 11 Ye (b0130) 2008; 374 Carnethon, Fortmann, Palaniappan, Duncan, Schmidt, Chambless (b0035) 2003; 158 Turner, Stratton, Horton, Manley, Zimmet, Mackay (b0210) 1997; 350 Ferrannini, Natali, Capaldo, Lehtovirta, Jacob, Yki-Jarvinen (b0015) 1997; 30 Wannamethee, Shaper (b0085) 1999; 22 Wei, Coady, Reis, Carnethon, Coresh, D'Agostino (b0095) 2015; 38 von Eckardstein, Sibler (b0160) 2011; 22 Kuwahara, Honda, Nakagawa, Yamamoto, Hayashi, Mizoue (b0045) 2017; 7 Samuel, Shulman (b0140) 2012; 148 Li, Fu, Koonen, Kuivenhoven, Snieder, Hofker (b0150) 2014; 233 Holzl, Iglseder, Sandhofer, Malaimare, Lang, Paulweber (b0180) 2002; 45 Katsuki, Sumida, Urakawa, Gabazza, Murashima, Maruyama (b0155) 2003; 26 Drew, Rye, Duffy, Barter, Kingwell (b0165) 2012; 8 Wajchenberg (b0105) 2000; 21 Mingrone, Henriksen, Greco, Krogh, Capristo, Gastaldelli (b0175) 1999; 48 Lee, Kwon, Yoo, Ahn, Yoon, Cha (b0240) 2009; 83 National Cholesterol Education Program Expert Panel on Detection E, Treatment of High Blood Cholesterol in A. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 2002, 106, 3143-421 Li (10.1016/j.diabres.2020.108050_b0150) 2014; 233 Peplies (10.1016/j.diabres.2020.108050_b0030) 2016; 13 Ye (10.1016/j.diabres.2020.108050_b0115) 2011; 38 White (10.1016/j.diabres.2020.108050_b0110) 2002; 283 Turner (10.1016/j.diabres.2020.108050_b0210) 1997; 350 Wei (10.1016/j.diabres.2020.108050_b0095) 2015; 38 Steiner (10.1016/j.diabres.2020.108050_b0170) 1982; 6 Stefan (10.1016/j.diabres.2020.108050_b0200) 2005; 90 Chen (10.1016/j.diabres.2020.108050_b0125) 2017; 16 Ferrannini (10.1016/j.diabres.2020.108050_b0015) 1997; 30 Samuel (10.1016/j.diabres.2020.108050_b0140) 2012; 148 Lopez-Rios (10.1016/j.diabres.2020.108050_b0205) 2011; 21 Katsuki (10.1016/j.diabres.2020.108050_b0155) 2003; 26 Ye (10.1016/j.diabres.2020.108050_b0010) 2013; 7 Zhou (10.1016/j.diabres.2020.108050_b0230) 2013; 62 Pihlajamaki (10.1016/j.diabres.2020.108050_b0195) 2000; 20 Petersen (10.1016/j.diabres.2020.108050_b0185) 2010; 362 Lakka (10.1016/j.diabres.2020.108050_b0020) 2002; 34 Biggs (10.1016/j.diabres.2020.108050_b0090) 2010; 303 Holzl (10.1016/j.diabres.2020.108050_b0180) 2002; 45 Robciuc (10.1016/j.diabres.2020.108050_b0190) 2013; 33 Vistisen (10.1016/j.diabres.2020.108050_b0040) 2014; 11 Kuwahara (10.1016/j.diabres.2020.108050_b0045) 2017; 7 Hill (10.1016/j.diabres.2020.108050_b0070) 2013; 36 Mingrone (10.1016/j.diabres.2020.108050_b0175) 1999; 48 Carnethon (10.1016/j.diabres.2020.108050_b0035) 2003; 158 Castro (10.1016/j.diabres.2020.108050_b0120) 2014; 58 Takeda (10.1016/j.diabres.2020.108050_b0235) 2002; 25 Li (10.1016/j.diabres.2020.108050_b0050) 2009; 404 Tuomi (10.1016/j.diabres.2020.108050_b0220) 1999; 48 Wannamethee (10.1016/j.diabres.2020.108050_b0085) 1999; 22 Drew (10.1016/j.diabres.2020.108050_b0165) 2012; 8 Lotta (10.1016/j.diabres.2020.108050_b0145) 2018; 320 Wajchenberg (10.1016/j.diabres.2020.108050_b0105) 2000; 21 Chang (10.1016/j.diabres.2020.108050_b0025) 2013; 8 10.1016/j.diabres.2020.108050_b0065 10.1016/j.diabres.2020.108050_b0060 Hawa (10.1016/j.diabres.2020.108050_b0225) 2014; 37 McArdle (10.1016/j.diabres.2020.108050_b0100) 2013; 4 Lowell (10.1016/j.diabres.2020.108050_b0135) 2005; 307 Ma (10.1016/j.diabres.2020.108050_b0055) 2013; 36 Lee (10.1016/j.diabres.2020.108050_b0240) 2009; 83 von Eckardstein (10.1016/j.diabres.2020.108050_b0160) 2011; 22 Moller (10.1016/j.diabres.2020.108050_b0005) 1991; 325 Ye (10.1016/j.diabres.2020.108050_b0130) 2008; 374 Radtke (10.1016/j.diabres.2020.108050_b0215) 2009; 32 Riserus (10.1016/j.diabres.2020.108050_b0080) 2007; 30 Gutt (10.1016/j.diabres.2020.108050_b0075) 2000; 47 |
| References_xml | – volume: 11 start-page: e1001602 year: 2014 ident: b0040 article-title: Patterns of obesity development before the diagnosis of type 2 diabetes: the Whitehall II cohort study publication-title: PLoS Med. contributor: fullname: Kivimaki – volume: 30 start-page: 1144 year: 1997 end-page: 1149 ident: b0015 article-title: Insulin resistance, hyperinsulinemia, and blood pressure: role of age and obesity. European Group for the Study of Insulin Resistance (EGIR) publication-title: Hypertension contributor: fullname: Yki-Jarvinen – volume: 148 start-page: 852 year: 2012 end-page: 871 ident: b0140 article-title: Mechanisms for insulin resistance: common threads and missing links publication-title: Cell contributor: fullname: Shulman – volume: 48 start-page: 1258 year: 1999 end-page: 1263 ident: b0175 article-title: Triglyceride-induced diabetes associated with familial lipoprotein lipase deficiency publication-title: Diabetes contributor: fullname: Gastaldelli – volume: 158 start-page: 1058 year: 2003 end-page: 1067 ident: b0035 article-title: Risk factors for progression to incident hyperinsulinemia: the Atherosclerosis Risk in Communities Study, 1987–1998 publication-title: Am J Epidemiol contributor: fullname: Chambless – volume: 307 start-page: 384 year: 2005 end-page: 387 ident: b0135 article-title: Mitochondrial dysfunction and type 2 diabetes publication-title: Science contributor: fullname: Shulman – volume: 4 start-page: 52 year: 2013 ident: b0100 article-title: Mechanisms of obesity-induced inflammation and insulin resistance: insights into the emerging role of nutritional strategies publication-title: Front Endocrinol (Lausanne). contributor: fullname: Roche – volume: 48 start-page: 150 year: 1999 end-page: 157 ident: b0220 article-title: Clinical and genetic characteristics of type 2 diabetes with and without GAD antibodies publication-title: Diabet contributor: fullname: Nilsson – volume: 34 start-page: 492 year: 2002 end-page: 498 ident: b0020 article-title: Obesity and weight gain are associated with increased incidence of hyperinsulinemia in non-diabetic men publication-title: Horm Metab Res. contributor: fullname: Lakka – volume: 22 start-page: 1266 year: 1999 end-page: 1272 ident: b0085 article-title: Weight change and duration of overweight and obesity in the incidence of type 2 diabetes publication-title: Diabet Care contributor: fullname: Shaper – volume: 320 start-page: 2553 year: 2018 end-page: 2563 ident: b0145 article-title: Association of genetic variants related to gluteofemoral vs abdominal fat distribution with type 2 diabetes, coronary disease, and cardiovascular risk factors publication-title: JAMA contributor: fullname: Luan – volume: 350 start-page: 1288 year: 1997 end-page: 1293 ident: b0210 article-title: UKPDS 25: autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes. UK prospective diabetes study Group publication-title: Lancet contributor: fullname: Mackay – volume: 13 start-page: 97 year: 2016 ident: b0030 article-title: Longitudinal associations of lifestyle factors and weight status with insulin resistance (HOMA-IR) in preadolescent children: the large prospective cohort study IDEFICS publication-title: Int J Behav Nutr Phys Act contributor: fullname: Veidebaum – volume: 7 start-page: 43521 year: 2017 ident: b0045 article-title: Body mass index trajectory patterns and changes in visceral fat and glucose metabolism before the onset of type 2 diabetes publication-title: Sci Rep contributor: fullname: Mizoue – volume: 47 start-page: 177 year: 2000 end-page: 184 ident: b0075 article-title: Validation of the insulin sensitivity index (ISI(0,120)): comparison with other measures publication-title: Diabetes Res Clin Pract contributor: fullname: Czarnecki – volume: 38 start-page: 2042 year: 2015 end-page: 2049 ident: b0095 article-title: Duration and degree of weight gain and incident diabetes in younger versus middle-aged black and white adults: ARIC, CARDIA, and the framingham heart study publication-title: Diabet Care contributor: fullname: D'Agostino – volume: 38 start-page: 872 year: 2011 end-page: 878 ident: b0115 article-title: Regulation of stem cell differentiation in adipose tissue by chronic inflammation publication-title: Clin Exp Pharmacol Physiol contributor: fullname: Gimble – volume: 6 start-page: 117 year: 1982 end-page: 124 ident: b0170 article-title: Hyperinsulinemia and hypertriglyceridemia, a vicious cycle with atherogenic potential publication-title: Int J Obes contributor: fullname: Vranic – volume: 33 start-page: 1706 year: 2013 end-page: 1713 ident: b0190 article-title: Angptl3 deficiency is associated with increased insulin sensitivity, lipoprotein lipase activity, and decreased serum free fatty acids publication-title: Arterioscler Thromb Vasc Biol contributor: fullname: Oorni – volume: 16 start-page: 203 year: 2017 ident: b0125 article-title: A vicious circle between insulin resistance and inflammation in nonalcoholic fatty liver disease publication-title: Lipids Health Dis. contributor: fullname: Zhu – volume: 303 start-page: 2504 year: 2010 end-page: 2512 ident: b0090 article-title: Association between adiposity in midlife and older age and risk of diabetes in older adults publication-title: JAMA contributor: fullname: Newman – volume: 20 start-page: 1789 year: 2000 end-page: 1795 ident: b0195 article-title: G-250A substitution in promoter of hepatic lipase gene is associated with dyslipidemia and insulin resistance in healthy control subjects and in members of families with familial combined hyperlipidemia publication-title: Arterioscler Thromb Vasc Biol contributor: fullname: Deeb – volume: 83 start-page: e62 year: 2009 end-page: e65 ident: b0240 article-title: Identifying latent autoimmune diabetes in adults in Korea: the role of C-peptide and metabolic syndrome publication-title: Diabet Res Clin Pract contributor: fullname: Cha – volume: 374 start-page: 405 year: 2008 end-page: 408 ident: b0130 article-title: Regulation of PPARgamma function by TNF-alpha publication-title: Biochem Biophys Res Commun contributor: fullname: Ye – volume: 32 start-page: 245 year: 2009 end-page: 250 ident: b0215 article-title: Heterogeneity of patients with latent autoimmune diabetes in adults: linkage to autoimmunity is apparent only in those with perceived need for insulin treatment: results from the Nord-Trondelag Health (HUNT) study publication-title: Diabet Care contributor: fullname: Grill – volume: 21 start-page: 18 year: 2011 end-page: 24 ident: b0205 article-title: Association of Taq 1B CETP polymorphism with insulin and HOMA levels in the population of the Canary Islands publication-title: Nutr Metab Cardiovasc Dis contributor: fullname: Novoa – volume: 36 start-page: 2324 year: 2013 end-page: 2330 ident: b0070 article-title: Expansion of the homeostasis model assessment of beta-cell function and insulin resistance to enable clinical trial outcome modeling through the interactive adjustment of physiology and treatment effects: iHOMA2 publication-title: Diabetes Care contributor: fullname: Matthews – volume: 22 start-page: 26 year: 2011 end-page: 32 ident: b0160 article-title: Possible contributions of lipoproteins and cholesterol to the pathogenesis of diabetes mellitus type 2 publication-title: Curr Opin Lipidol contributor: fullname: Sibler – volume: 25 start-page: 995 year: 2002 end-page: 1001 ident: b0235 article-title: Clinical, autoimmune, and genetic characteristics of adult-onset diabetic patients with GAD autoantibodies in Japan (Ehime Study) publication-title: Diabet Care contributor: fullname: Murao – volume: 362 start-page: 1082 year: 2010 end-page: 1089 ident: b0185 article-title: Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease publication-title: N Engl J Med contributor: fullname: Zhang – volume: 404 start-page: 149 year: 2009 end-page: 153 ident: b0050 article-title: Serum vascular adhesion protein-1 is increased in acute and chronic hyperglycemia Clinica chimica acta publication-title: Int J Clin Chem contributor: fullname: Lin – volume: 37 start-page: 1643 year: 2014 end-page: 1649 ident: b0225 article-title: LADA and CARDS: a prospective study of clinical outcome in established adult-onset autoimmune diabetes publication-title: Diabet Care contributor: fullname: Bao – volume: 233 start-page: 130 year: 2014 end-page: 138 ident: b0150 article-title: Are hypertriglyceridemia and low HDL causal factors in the development of insulin resistance? publication-title: Atherosclerosis contributor: fullname: Hofker – volume: 45 start-page: 378 year: 2002 end-page: 384 ident: b0180 article-title: Insulin sensitivity is impaired in heterozygous carriers of lipoprotein lipase deficiency publication-title: Diabetologia contributor: fullname: Paulweber – volume: 325 start-page: 938 year: 1991 end-page: 948 ident: b0005 article-title: Insulin resistance–mechanisms, syndromes, and implications publication-title: N Engl J Med contributor: fullname: Flier – volume: 21 start-page: 697 year: 2000 end-page: 738 ident: b0105 article-title: Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome publication-title: Endocr Rev. contributor: fullname: Wajchenberg – volume: 26 start-page: 2341 year: 2003 end-page: 2344 ident: b0155 article-title: Increased visceral fat and serum levels of triglyceride are associated with insulin resistance in Japanese metabolically obese, normal weight subjects with normal glucose tolerance publication-title: Diabet Care contributor: fullname: Maruyama – volume: 90 start-page: 4238 year: 2005 end-page: 4243 ident: b0200 article-title: Liver fat and insulin resistance are independently associated with the -514C>T polymorphism of the hepatic lipase gene publication-title: J Clin Endocrinol Metab contributor: fullname: Claussen – volume: 7 start-page: 14 year: 2013 end-page: 24 ident: b0010 article-title: Mechanisms of insulin resistance in obesity publication-title: Front Med contributor: fullname: Ye – volume: 58 start-page: 600 year: 2014 end-page: 609 ident: b0120 article-title: Obesity, insulin resistance and comorbidities? Mechanisms of association publication-title: Arq Bras Endocrinol Metabol contributor: fullname: Bergman – volume: 8 start-page: 237 year: 2012 end-page: 245 ident: b0165 article-title: The emerging role of HDL in glucose metabolism publication-title: Nat Rev Endocrinol contributor: fullname: Kingwell – volume: 283 start-page: E413 year: 2002 end-page: E422 ident: b0110 article-title: IRS proteins and the common path to diabetes publication-title: Am J Physiol Endocrinol Metab contributor: fullname: White – volume: 30 start-page: 2928 year: 2007 end-page: 2933 ident: b0080 article-title: Long-term predictors of insulin resistance: role of lifestyle and metabolic factors in middle-aged men publication-title: Diabetes Care contributor: fullname: Berglund – volume: 36 start-page: 1660 year: 2013 end-page: 1666 ident: b0055 article-title: Measurement of Waist Circumference: midabdominal or iliac crest? publication-title: Diabetes Care contributor: fullname: Chiu – volume: 62 start-page: 543 year: 2013 end-page: 550 ident: b0230 article-title: Frequency, immunogenetics, and clinical characteristics of latent autoimmune diabetes in China (LADA China study): a nationwide, multicenter, clinic-based cross-sectional study publication-title: Diabetes contributor: fullname: Huang – volume: 8 year: 2013 ident: b0025 article-title: Weight change as a predictor of incidence and remission of insulin resistance publication-title: PLoS ONE contributor: fullname: Kwon – volume: 45 start-page: 378 year: 2002 ident: 10.1016/j.diabres.2020.108050_b0180 article-title: Insulin sensitivity is impaired in heterozygous carriers of lipoprotein lipase deficiency publication-title: Diabetologia doi: 10.1007/s00125-001-0771-8 contributor: fullname: Holzl – volume: 90 start-page: 4238 year: 2005 ident: 10.1016/j.diabres.2020.108050_b0200 article-title: Liver fat and insulin resistance are independently associated with the -514C>T polymorphism of the hepatic lipase gene publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2004-2479 contributor: fullname: Stefan – volume: 7 start-page: 43521 year: 2017 ident: 10.1016/j.diabres.2020.108050_b0045 article-title: Body mass index trajectory patterns and changes in visceral fat and glucose metabolism before the onset of type 2 diabetes publication-title: Sci Rep doi: 10.1038/srep43521 contributor: fullname: Kuwahara – volume: 7 start-page: 14 year: 2013 ident: 10.1016/j.diabres.2020.108050_b0010 article-title: Mechanisms of insulin resistance in obesity publication-title: Front Med doi: 10.1007/s11684-013-0262-6 contributor: fullname: Ye – volume: 307 start-page: 384 year: 2005 ident: 10.1016/j.diabres.2020.108050_b0135 article-title: Mitochondrial dysfunction and type 2 diabetes publication-title: Science doi: 10.1126/science.1104343 contributor: fullname: Lowell – volume: 21 start-page: 697 year: 2000 ident: 10.1016/j.diabres.2020.108050_b0105 article-title: Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome publication-title: Endocr Rev. doi: 10.1210/edrv.21.6.0415 contributor: fullname: Wajchenberg – volume: 38 start-page: 872 year: 2011 ident: 10.1016/j.diabres.2020.108050_b0115 article-title: Regulation of stem cell differentiation in adipose tissue by chronic inflammation publication-title: Clin Exp Pharmacol Physiol doi: 10.1111/j.1440-1681.2011.05596.x contributor: fullname: Ye – volume: 374 start-page: 405 year: 2008 ident: 10.1016/j.diabres.2020.108050_b0130 article-title: Regulation of PPARgamma function by TNF-alpha publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2008.07.068 contributor: fullname: Ye – volume: 33 start-page: 1706 year: 2013 ident: 10.1016/j.diabres.2020.108050_b0190 article-title: Angptl3 deficiency is associated with increased insulin sensitivity, lipoprotein lipase activity, and decreased serum free fatty acids publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/ATVBAHA.113.301397 contributor: fullname: Robciuc – volume: 350 start-page: 1288 year: 1997 ident: 10.1016/j.diabres.2020.108050_b0210 article-title: UKPDS 25: autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes. UK prospective diabetes study Group publication-title: Lancet doi: 10.1016/S0140-6736(97)03062-6 contributor: fullname: Turner – volume: 233 start-page: 130 year: 2014 ident: 10.1016/j.diabres.2020.108050_b0150 article-title: Are hypertriglyceridemia and low HDL causal factors in the development of insulin resistance? publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2013.12.013 contributor: fullname: Li – volume: 20 start-page: 1789 year: 2000 ident: 10.1016/j.diabres.2020.108050_b0195 article-title: G-250A substitution in promoter of hepatic lipase gene is associated with dyslipidemia and insulin resistance in healthy control subjects and in members of families with familial combined hyperlipidemia publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/01.ATV.20.7.1789 contributor: fullname: Pihlajamaki – volume: 320 start-page: 2553 year: 2018 ident: 10.1016/j.diabres.2020.108050_b0145 article-title: Association of genetic variants related to gluteofemoral vs abdominal fat distribution with type 2 diabetes, coronary disease, and cardiovascular risk factors publication-title: JAMA doi: 10.1001/jama.2018.19329 contributor: fullname: Lotta – volume: 6 start-page: 117 issue: Suppl 1 year: 1982 ident: 10.1016/j.diabres.2020.108050_b0170 article-title: Hyperinsulinemia and hypertriglyceridemia, a vicious cycle with atherogenic potential publication-title: Int J Obes contributor: fullname: Steiner – volume: 37 start-page: 1643 year: 2014 ident: 10.1016/j.diabres.2020.108050_b0225 article-title: LADA and CARDS: a prospective study of clinical outcome in established adult-onset autoimmune diabetes publication-title: Diabet Care doi: 10.2337/dc13-2383 contributor: fullname: Hawa – volume: 62 start-page: 543 year: 2013 ident: 10.1016/j.diabres.2020.108050_b0230 article-title: Frequency, immunogenetics, and clinical characteristics of latent autoimmune diabetes in China (LADA China study): a nationwide, multicenter, clinic-based cross-sectional study publication-title: Diabetes doi: 10.2337/db12-0207 contributor: fullname: Zhou – volume: 48 start-page: 1258 year: 1999 ident: 10.1016/j.diabres.2020.108050_b0175 article-title: Triglyceride-induced diabetes associated with familial lipoprotein lipase deficiency publication-title: Diabetes doi: 10.2337/diabetes.48.6.1258 contributor: fullname: Mingrone – volume: 21 start-page: 18 year: 2011 ident: 10.1016/j.diabres.2020.108050_b0205 article-title: Association of Taq 1B CETP polymorphism with insulin and HOMA levels in the population of the Canary Islands publication-title: Nutr Metab Cardiovasc Dis doi: 10.1016/j.numecd.2009.06.009 contributor: fullname: Lopez-Rios – ident: 10.1016/j.diabres.2020.108050_b0060 doi: 10.2337/dc18-S002 – volume: 47 start-page: 177 year: 2000 ident: 10.1016/j.diabres.2020.108050_b0075 article-title: Validation of the insulin sensitivity index (ISI(0,120)): comparison with other measures publication-title: Diabetes Res Clin Pract doi: 10.1016/S0168-8227(99)00116-3 contributor: fullname: Gutt – volume: 83 start-page: e62 year: 2009 ident: 10.1016/j.diabres.2020.108050_b0240 article-title: Identifying latent autoimmune diabetes in adults in Korea: the role of C-peptide and metabolic syndrome publication-title: Diabet Res Clin Pract doi: 10.1016/j.diabres.2008.11.031 contributor: fullname: Lee – volume: 36 start-page: 2324 year: 2013 ident: 10.1016/j.diabres.2020.108050_b0070 article-title: Expansion of the homeostasis model assessment of beta-cell function and insulin resistance to enable clinical trial outcome modeling through the interactive adjustment of physiology and treatment effects: iHOMA2 publication-title: Diabetes Care doi: 10.2337/dc12-0607 contributor: fullname: Hill – volume: 362 start-page: 1082 year: 2010 ident: 10.1016/j.diabres.2020.108050_b0185 article-title: Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease publication-title: N Engl J Med doi: 10.1056/NEJMoa0907295 contributor: fullname: Petersen – volume: 25 start-page: 995 year: 2002 ident: 10.1016/j.diabres.2020.108050_b0235 article-title: Clinical, autoimmune, and genetic characteristics of adult-onset diabetic patients with GAD autoantibodies in Japan (Ehime Study) publication-title: Diabet Care doi: 10.2337/diacare.25.6.995 contributor: fullname: Takeda – volume: 158 start-page: 1058 year: 2003 ident: 10.1016/j.diabres.2020.108050_b0035 article-title: Risk factors for progression to incident hyperinsulinemia: the Atherosclerosis Risk in Communities Study, 1987–1998 publication-title: Am J Epidemiol doi: 10.1093/aje/kwg260 contributor: fullname: Carnethon – volume: 26 start-page: 2341 year: 2003 ident: 10.1016/j.diabres.2020.108050_b0155 article-title: Increased visceral fat and serum levels of triglyceride are associated with insulin resistance in Japanese metabolically obese, normal weight subjects with normal glucose tolerance publication-title: Diabet Care doi: 10.2337/diacare.26.8.2341 contributor: fullname: Katsuki – volume: 22 start-page: 26 year: 2011 ident: 10.1016/j.diabres.2020.108050_b0160 article-title: Possible contributions of lipoproteins and cholesterol to the pathogenesis of diabetes mellitus type 2 publication-title: Curr Opin Lipidol doi: 10.1097/MOL.0b013e3283412279 contributor: fullname: von Eckardstein – volume: 34 start-page: 492 year: 2002 ident: 10.1016/j.diabres.2020.108050_b0020 article-title: Obesity and weight gain are associated with increased incidence of hyperinsulinemia in non-diabetic men publication-title: Horm Metab Res. doi: 10.1055/s-2002-34788 contributor: fullname: Lakka – volume: 4 start-page: 52 year: 2013 ident: 10.1016/j.diabres.2020.108050_b0100 article-title: Mechanisms of obesity-induced inflammation and insulin resistance: insights into the emerging role of nutritional strategies publication-title: Front Endocrinol (Lausanne). doi: 10.3389/fendo.2013.00052 contributor: fullname: McArdle – volume: 404 start-page: 149 year: 2009 ident: 10.1016/j.diabres.2020.108050_b0050 article-title: Serum vascular adhesion protein-1 is increased in acute and chronic hyperglycemia Clinica chimica acta publication-title: Int J Clin Chem contributor: fullname: Li – volume: 22 start-page: 1266 year: 1999 ident: 10.1016/j.diabres.2020.108050_b0085 article-title: Weight change and duration of overweight and obesity in the incidence of type 2 diabetes publication-title: Diabet Care doi: 10.2337/diacare.22.8.1266 contributor: fullname: Wannamethee – volume: 13 start-page: 97 year: 2016 ident: 10.1016/j.diabres.2020.108050_b0030 article-title: Longitudinal associations of lifestyle factors and weight status with insulin resistance (HOMA-IR) in preadolescent children: the large prospective cohort study IDEFICS publication-title: Int J Behav Nutr Phys Act doi: 10.1186/s12966-016-0424-4 contributor: fullname: Peplies – volume: 283 start-page: E413 year: 2002 ident: 10.1016/j.diabres.2020.108050_b0110 article-title: IRS proteins and the common path to diabetes publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00514.2001 contributor: fullname: White – volume: 58 start-page: 600 year: 2014 ident: 10.1016/j.diabres.2020.108050_b0120 article-title: Obesity, insulin resistance and comorbidities? Mechanisms of association publication-title: Arq Bras Endocrinol Metabol doi: 10.1590/0004-2730000003223 contributor: fullname: Castro – volume: 8 year: 2013 ident: 10.1016/j.diabres.2020.108050_b0025 article-title: Weight change as a predictor of incidence and remission of insulin resistance publication-title: PLoS ONE contributor: fullname: Chang – volume: 303 start-page: 2504 year: 2010 ident: 10.1016/j.diabres.2020.108050_b0090 article-title: Association between adiposity in midlife and older age and risk of diabetes in older adults publication-title: JAMA doi: 10.1001/jama.2010.843 contributor: fullname: Biggs – volume: 30 start-page: 1144 year: 1997 ident: 10.1016/j.diabres.2020.108050_b0015 article-title: Insulin resistance, hyperinsulinemia, and blood pressure: role of age and obesity. European Group for the Study of Insulin Resistance (EGIR) publication-title: Hypertension doi: 10.1161/01.HYP.30.5.1144 contributor: fullname: Ferrannini – volume: 11 start-page: e1001602 year: 2014 ident: 10.1016/j.diabres.2020.108050_b0040 article-title: Patterns of obesity development before the diagnosis of type 2 diabetes: the Whitehall II cohort study publication-title: PLoS Med. doi: 10.1371/journal.pmed.1001602 contributor: fullname: Vistisen – volume: 16 start-page: 203 year: 2017 ident: 10.1016/j.diabres.2020.108050_b0125 article-title: A vicious circle between insulin resistance and inflammation in nonalcoholic fatty liver disease publication-title: Lipids Health Dis. doi: 10.1186/s12944-017-0572-9 contributor: fullname: Chen – ident: 10.1016/j.diabres.2020.108050_b0065 doi: 10.1161/circ.106.25.3143 – volume: 30 start-page: 2928 year: 2007 ident: 10.1016/j.diabres.2020.108050_b0080 article-title: Long-term predictors of insulin resistance: role of lifestyle and metabolic factors in middle-aged men publication-title: Diabetes Care doi: 10.2337/dc07-0360 contributor: fullname: Riserus – volume: 325 start-page: 938 year: 1991 ident: 10.1016/j.diabres.2020.108050_b0005 article-title: Insulin resistance–mechanisms, syndromes, and implications publication-title: N Engl J Med doi: 10.1056/NEJM199109263251307 contributor: fullname: Moller – volume: 148 start-page: 852 year: 2012 ident: 10.1016/j.diabres.2020.108050_b0140 article-title: Mechanisms for insulin resistance: common threads and missing links publication-title: Cell doi: 10.1016/j.cell.2012.02.017 contributor: fullname: Samuel – volume: 32 start-page: 245 year: 2009 ident: 10.1016/j.diabres.2020.108050_b0215 article-title: Heterogeneity of patients with latent autoimmune diabetes in adults: linkage to autoimmunity is apparent only in those with perceived need for insulin treatment: results from the Nord-Trondelag Health (HUNT) study publication-title: Diabet Care doi: 10.2337/dc08-1468 contributor: fullname: Radtke – volume: 8 start-page: 237 year: 2012 ident: 10.1016/j.diabres.2020.108050_b0165 article-title: The emerging role of HDL in glucose metabolism publication-title: Nat Rev Endocrinol doi: 10.1038/nrendo.2011.235 contributor: fullname: Drew – volume: 48 start-page: 150 year: 1999 ident: 10.1016/j.diabres.2020.108050_b0220 article-title: Clinical and genetic characteristics of type 2 diabetes with and without GAD antibodies publication-title: Diabet doi: 10.2337/diabetes.48.1.150 contributor: fullname: Tuomi – volume: 38 start-page: 2042 year: 2015 ident: 10.1016/j.diabres.2020.108050_b0095 article-title: Duration and degree of weight gain and incident diabetes in younger versus middle-aged black and white adults: ARIC, CARDIA, and the framingham heart study publication-title: Diabet Care doi: 10.2337/dc14-2770 contributor: fullname: Wei – volume: 36 start-page: 1660 year: 2013 ident: 10.1016/j.diabres.2020.108050_b0055 article-title: Measurement of Waist Circumference: midabdominal or iliac crest? publication-title: Diabetes Care doi: 10.2337/dc12-1452 contributor: fullname: Ma |
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| Title | Progression of insulin resistance: A link between risk factors and the incidence of diabetes |
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