Preclinical assessment of the neutralizing efficacy of snake antivenoms in Latin America and the Caribbean: A review

• Published in: Toxicon (Oxford) Vol. 146; pp. 138 - 150
• Main Author: Gutiérrez, José María
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.05.2018
• Subjects: Animals; Antivenins - pharmacology; Antivenoms; Latin America; Neutralization; Neutralization Tests; Preclinical evaluation; Snake venoms; Snake Venoms - antagonists & inhibitors; Snake Venoms - toxicity; Snakes; The Caribbean; Latin America; Preclinical evaluation; Antivenoms; The Caribbean; Snake venoms; Neutralization; Latin America

The preclinical evaluation of the neutralizing efficacy of antivenoms is mandatory before a product is introduced for clinical use. The World Health Organization (WHO) guidelines for antivenoms categorize the tests used in preclinical studies as ‘essential assay’ (neutralization of lethality) and ‘a...