Baseline Hepatitis C Virus NS5A Resistance-Associated Polymorphisms in Patients With and Without Human Immunodeficiency Virus Coinfection in Mexico

• Published in: Microbial drug resistance (Larchmont, N.Y.) Vol. 27; no. 9; p. 1195
• Main Authors: Lopez Luis, Bruno Ali, Angulo-Medina, Luis, Rodriguez-Diaz, Roberto, Soto-Ramírez, Luis Enrique
• Format: Journal Article
• Language: English
• Published: United States 01.09.2021
• Subjects: Adult; Antiviral Agents - pharmacology; Drug Resistance, Viral - drug effects; Female; Hepacivirus - genetics; Hepatitis C - epidemiology; HIV Infections - epidemiology; Humans; Male; Mexico - epidemiology; Microbiological Techniques; Polymorphism, Genetic; RNA-Dependent RNA Polymerase - genetics; Viral Nonstructural Proteins - genetics; Mexico; fibrosis; drug resistance; antiviral agents; coinfection; hepatitis C; genotype

We aimed to evaluate the frequency and associated factors of baseline NS5A resistance-associated substitutions (RASs) in patients coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) monoinfection with genotype 1b (GT1b) or genotype 1a (GT1a). Moreover, we performed a phylo...