Baseline Hepatitis C Virus NS5A Resistance-Associated Polymorphisms in Patients With and Without Human Immunodeficiency Virus Coinfection in Mexico
We aimed to evaluate the frequency and associated factors of baseline NS5A resistance-associated substitutions (RASs) in patients coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) monoinfection with genotype 1b (GT1b) or genotype 1a (GT1a). Moreover, we performed a phylo...
Saved in:
Published in | Microbial drug resistance (Larchmont, N.Y.) Vol. 27; no. 9; p. 1195 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.09.2021
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Abstract | We aimed to evaluate the frequency and associated factors of baseline NS5A resistance-associated substitutions (RASs) in patients coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) monoinfection with genotype 1b (GT1b) or genotype 1a (GT1a). Moreover, we performed a phylogenetic analysis to evaluate the pattern of clustering among samples of patients with RASs.
Fifty-five patients were infected with GT1a, of whom 44 (80%) were HIV-infected patients. RAS prevalence in GT1a was 14% (6/44) and distributed as follows: 5 (11%) harbored M28V and 1 (2%) A92T. Twenty-four patients were infected with HCV GT1b, of whom only 5 (21%) were HIV coinfected; RASs were found in 17/24 (71%) patients, as follows: Y93H+F37L+Q54H (1/24), Y93H+F37L (1/24), P58S (1/24), L31F+F37L (1/24), F37L+H/Q54H (3/24), and F37L (10/24). Only GT1b was significantly associated with RASs (adjusted odds ratio 16.37; 95% confidence interval 2.74-97.48;
= 0.002) in the multivariate analysis. A cluster of sequences from HIV/HCV GT1a patients was found; however, we did not find phylogenetic relationships among sequences with NS5A RASs.
In our population of HCV-infected patients, the frequency of NS5A RASs at baseline was somewhat similar to the previously reported worldwide rate. HCV GT1b showed the most significant association with harboring of NS5A RASs. Of note, despite there being clusters among sequences of HIV-coinfected patients, NS5A RASs were not transmitted. |
---|---|
AbstractList | We aimed to evaluate the frequency and associated factors of baseline NS5A resistance-associated substitutions (RASs) in patients coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) monoinfection with genotype 1b (GT1b) or genotype 1a (GT1a). Moreover, we performed a phylogenetic analysis to evaluate the pattern of clustering among samples of patients with RASs.
Fifty-five patients were infected with GT1a, of whom 44 (80%) were HIV-infected patients. RAS prevalence in GT1a was 14% (6/44) and distributed as follows: 5 (11%) harbored M28V and 1 (2%) A92T. Twenty-four patients were infected with HCV GT1b, of whom only 5 (21%) were HIV coinfected; RASs were found in 17/24 (71%) patients, as follows: Y93H+F37L+Q54H (1/24), Y93H+F37L (1/24), P58S (1/24), L31F+F37L (1/24), F37L+H/Q54H (3/24), and F37L (10/24). Only GT1b was significantly associated with RASs (adjusted odds ratio 16.37; 95% confidence interval 2.74-97.48;
= 0.002) in the multivariate analysis. A cluster of sequences from HIV/HCV GT1a patients was found; however, we did not find phylogenetic relationships among sequences with NS5A RASs.
In our population of HCV-infected patients, the frequency of NS5A RASs at baseline was somewhat similar to the previously reported worldwide rate. HCV GT1b showed the most significant association with harboring of NS5A RASs. Of note, despite there being clusters among sequences of HIV-coinfected patients, NS5A RASs were not transmitted. |
Author | Angulo-Medina, Luis Lopez Luis, Bruno Ali Soto-Ramírez, Luis Enrique Rodriguez-Diaz, Roberto |
Author_xml | – sequence: 1 givenname: Bruno Ali surname: Lopez Luis fullname: Lopez Luis, Bruno Ali organization: Laboratory of Molecular Virology, Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico – sequence: 2 givenname: Luis surname: Angulo-Medina fullname: Angulo-Medina, Luis organization: Laboratory of Molecular Virology, Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico – sequence: 3 givenname: Roberto surname: Rodriguez-Diaz fullname: Rodriguez-Diaz, Roberto organization: Laboratory of Molecular Virology, Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico – sequence: 4 givenname: Luis Enrique surname: Soto-Ramírez fullname: Soto-Ramírez, Luis Enrique organization: Laboratory of Molecular Virology, Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33794105$$D View this record in MEDLINE/PubMed |
BookMark | eNo1UEtLAzEYDKLYhx69Sv7A1myS3W6OdVFbqFp8Hks2-UIjTbJssmB_h3_YqvU0wzAPmBE69sEDQhc5meSkEldOdxNKKJkQzsojNMwFy7OK82qARjF-EEKKvGSnaMDYVPCcFEP0dS0jbK0HPIdWJptsxDV-s10f8cNzMcNPEG1M0ivIZjEGZWUCjVdhu3Ohazc2uoitx6t9FnyK-N2mDZZe_5LQJzzvnfR44VzvgwZj1d6ndoeJOlhvQCUb_E_LPXxaFc7QiZHbCOcHHKPX25uXep4tH-8W9WyZKVYWKSu0mEqhDG1E3tBKgSFMUMYN4aLhqiw4UGMYUZQRo2QhqNAV43IvgNSqomN0-dfb9o0DvW4762S3W_-_Q78BWHhprA |
CitedBy_id | crossref_primary_10_1097_OLQ_0000000000001596 crossref_primary_10_18470_1992_1098_2024_1_4 |
ContentType | Journal Article |
DBID | CGR CUY CVF ECM EIF NPM |
DOI | 10.1089/mdr.2020.0436 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | no_fulltext_linktorsrc |
Discipline | Medicine Biology Pharmacy, Therapeutics, & Pharmacology |
EISSN | 1931-8448 |
ExternalDocumentID | 33794105 |
Genre | Journal Article |
GeographicLocations | Mexico |
GeographicLocations_xml | – name: Mexico |
GroupedDBID | --- .GJ 0R~ 1-M 123 29M 34G 39C 3V. 4.4 53G 6AZ 7X7 88A 88E 88I 8C1 8FE 8FH 8FI 8FJ AAHBH ABBKN ABUWG ACGFS ACGOD ACIWK ACPRK ADBBV AENEX AFKRA AFRAH AHMBA ALIPV ALMA_UNASSIGNED_HOLDINGS AZQEC BBNVY BENPR BHPHI BNQNF BPHCQ BVXVI CAG CCPQU CGR COF CS3 CUY CVF DU5 DWQXO EBS ECM EIF EJD F5P FYUFA GNUQQ HCIFZ HMCUK IAO IER IHR IM4 INH INR ITC LK8 M0L M1P M2P M7P MV1 NPM NQHIM O9- P2P PQQKQ PROAC PSQYO RIG RML RMSOB UE5 UKHRP |
ID | FETCH-LOGICAL-c365t-5d97a9cf2b91b28cef039234f049b4c654e2ff30c230fca5929d834a0c2eadc82 |
IngestDate | Sat Sep 28 08:33:38 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 9 |
Keywords | fibrosis drug resistance antiviral agents coinfection hepatitis C genotype |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c365t-5d97a9cf2b91b28cef039234f049b4c654e2ff30c230fca5929d834a0c2eadc82 |
PMID | 33794105 |
ParticipantIDs | pubmed_primary_33794105 |
PublicationCentury | 2000 |
PublicationDate | 2021-Sep |
PublicationDateYYYYMMDD | 2021-09-01 |
PublicationDate_xml | – month: 09 year: 2021 text: 2021-Sep |
PublicationDecade | 2020 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | Microbial drug resistance (Larchmont, N.Y.) |
PublicationTitleAlternate | Microb Drug Resist |
PublicationYear | 2021 |
SSID | ssj0005163 |
Score | 2.3474715 |
Snippet | We aimed to evaluate the frequency and associated factors of baseline NS5A resistance-associated substitutions (RASs) in patients coinfected with human... |
SourceID | pubmed |
SourceType | Index Database |
StartPage | 1195 |
SubjectTerms | Adult Antiviral Agents - pharmacology Drug Resistance, Viral - drug effects Female Hepacivirus - genetics Hepatitis C - epidemiology HIV Infections - epidemiology Humans Male Mexico - epidemiology Microbiological Techniques Polymorphism, Genetic RNA-Dependent RNA Polymerase - genetics Viral Nonstructural Proteins - genetics |
Title | Baseline Hepatitis C Virus NS5A Resistance-Associated Polymorphisms in Patients With and Without Human Immunodeficiency Virus Coinfection in Mexico |
URI | https://www.ncbi.nlm.nih.gov/pubmed/33794105 |
Volume | 27 |
hasFullText | |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb5tAEF45rRrlUrXu-6U9VLkQUl6L4Zg6qdKqjqzWqXKLYNm1kGywMEi1_0Z_a--d2eVhW676uCC8i2HFfAwzu998EPIWIvyEcx6YPoPcxEuEY4YMfnIBaA4d6dmqvmJ05V9ee59u2E2v93ODtVSV8Slf760r-R-rQhvYFatk_8Gy7UmhAfbBvrAFC8P2r2z8PlLl5AJeHkiMLtOlMTS-pUUFzusrQ6bbEsNDsKvZmAHiy3E-g4Qf7m-6nCs27FhrqyIVti50wx0kLOsp_o9YQ5InAsUmVKWmvsQwb5hcii05Et8BVZvB7ihVKk-4DFRUU6NoR6O-I4JPGNypcqveq2YH5QuxNj5XWv8AxRFy42yWdlMW02qWm7jGpCva8Mhu5Sgp0mkl1uZ5Gq078njeziXlZW5-gecAKQLnhZ5BxzMYF1mRag56OxHi2C3TC95j2nmHrm0GnlbubLy7Vh6oURxuuGrUutv7DrEClGCdJ6gW61inqNG_eRxAYDFXgHJdcGa2xf7cuyPp3XQdkINBgG75CqeYGl4SRMi1GCyM5N3WOI7IYfPfnTRIhUOTB-R-ncfQMw3Kh6Qnsj65p79suuqTw1HN2eiT47FWR1-d0ElX7Lc8ocd03Ommrx6RHw2caQtnOqQKaxThTPfCmW7BmaYZbeBMEcUU4ExrOFMFZ7oL5_oSG3DGs2g4PybXHy4mw0uz_maIyV2flSZLwkEUcunEoR07ARfSggzA9SRkwrHHfeYJR0rX4pB6Sx4xyA6SwPUiaACfygPnCbmT5Zl4RmjkyghihSD0_cALLBF5A3BrlmRJDAdb0XPyVFvgdqGFYW4b27z4bc9LctRB9xW5K8ETidcQ1pbxGwWDX0wIqLY |
link.rule.ids | 786 |
linkProvider | National Library of Medicine |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Baseline+Hepatitis+C+Virus+NS5A+Resistance-Associated+Polymorphisms+in+Patients+With+and+Without+Human+Immunodeficiency+Virus+Coinfection+in+Mexico&rft.jtitle=Microbial+drug+resistance+%28Larchmont%2C+N.Y.%29&rft.au=Lopez+Luis%2C+Bruno+Ali&rft.au=Angulo-Medina%2C+Luis&rft.au=Rodriguez-Diaz%2C+Roberto&rft.au=Soto-Ram%C3%ADrez%2C+Luis+Enrique&rft.date=2021-09-01&rft.eissn=1931-8448&rft.volume=27&rft.issue=9&rft.spage=1195&rft_id=info:doi/10.1089%2Fmdr.2020.0436&rft_id=info%3Apmid%2F33794105&rft_id=info%3Apmid%2F33794105&rft.externalDocID=33794105 |