Recent developments in our understanding of the physiological role of PP-fold peptide receptor subtypes

• Published in: Experimental biology and medicine (Maywood, N.J.) Vol. 228; no. 3; p. 217
• Main Authors: Berglund, Magnus M, Hipskind, Philip A, Gehlert, Donald R
• Format: Journal Article
• Language: English
• Published: England 01.03.2003
• Subjects: Amino Acid Sequence; Animals; Mice; Mice, Knockout; Molecular Sequence Data; Neuropeptide Y - genetics; Neuropeptide Y - metabolism; Neuropeptide Y - physiology; Pancreatic Polypeptide - genetics; Pancreatic Polypeptide - metabolism; Pancreatic Polypeptide - physiology; Peptide YY - genetics; Peptide YY - metabolism; Peptide YY - physiology; Rats; Receptors, Peptide - chemistry; Receptors, Peptide - metabolism

The three peptides pancreatic polypeptide (PP), peptide YY (PYY), and neuropeptide Y (NPY) share a similar structure known as the PP-fold. There are four known human G-protein coupled receptors for the PP-fold peptides, namely Y1, Y2, Y4, and Y5, each of them being able to bind at least two of the t...