The role of delta-1-pyrroline-5-carboxylate dehydrogenase (P5CDh) in the Pacific white shrimp (Litopenaeus vannamei) during biotic and abiotic stress

• Published in: Aquatic toxicology Vol. 208; pp. 1 - 11
• Main Authors: Liang, QingJian, Wu, XuJian, Yang, Pan, Kong, JinRong, Wei, Wei, Qiao, Xueli, Liu, Yuan, Wang, Weina
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2019
• Subjects: Hypersensitive response; Litopenaeus vannamei; p53; P5CDh; Subcellular localization; P5CDh; Hypersensitive response; Litopenaeus vannamei; Subcellular localization; p53

•Biotic and different abiotic stress induced significant P5CDh gene expression and Pro accumulate.•Overexpression of P5CDh can reduce ROS and apoptosis, thereby protecting cells.•p53 silencing can indirectly reduce P5CDh expression. Proline (Pro) metabolism is intimately associated with stress adapt...