Yeast cell membrane-camouflaged PLGA nanoparticle platform for enhanced cancer therapy
Temozolomide (TMZ) is an oral DNA-alkylating drug used in colorectal cancer (CRC) chemotherapy. In this work, we proposed a safe and biomimetic platform for macrophages-targeted delivery of TMZ and O6-benzylguanine (O6-BG). TMZ was loaded in poly (D, l-lactide-coglycolide) (PLGA) nanoparticles, foll...
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| Published in | Journal of controlled release Vol. 359; pp. 347 - 358 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.07.2023
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| Abstract | Temozolomide (TMZ) is an oral DNA-alkylating drug used in colorectal cancer (CRC) chemotherapy. In this work, we proposed a safe and biomimetic platform for macrophages-targeted delivery of TMZ and O6-benzylguanine (O6-BG). TMZ was loaded in poly (D, l-lactide-coglycolide) (PLGA) nanoparticles, followed by sequential coating with O6-BG-grafted chitosan (BG-CS) layers and yeast shell walls (YSW) via layer-by-layer assembly (LBL) process, forming TMZ@P-BG/YSW biohybrids. Due to the yeast cell membrane-camouflage, TMZ@P-BG/YSW particles exhibited significantly enhanced colloidal stability as well as low premature drug leakage in simulated gastrointestinal conditions. In vitro drug release profiles of TMZ@P-BG/YSW particles revealed noticeable higher TMZ release in simulated tumor acidic environment within 72 h. Meanwhile, O6-BG could down-regulate MGMT expression in CT26 colon carcinoma cells, ultimately facilitating TMZ-induced tumor cell death. After oral delivery of yeast cell membrane-camouflaged particles containing fluorescent tracer (Cy5), TMZ@P-BG/YSW and bare YSW displayed high retention time of 12 h in the colon and small intestine (ileum). Correspondingly, oral gavage administration of TMZ@P-BG/YSW particles afforded favorable tumor-specific retention and superior tumor growth inhibition. Overall, TMZ@P-BG/YSW is validated to be a safe, targetable and effective formulation, paving a new avenue towards highly effective and precise treatment of malignancies.
PLGA-based bioinspired platform for tumor-specific retention and enhanced colorectal cancer therapy. [Display omitted] |
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| AbstractList | Temozolomide (TMZ) is an oral DNA-alkylating drug used in colorectal cancer (CRC) chemotherapy. In this work, we proposed a safe and biomimetic platform for macrophages-targeted delivery of TMZ and O6-benzylguanine (O6-BG). TMZ was loaded in poly (D, l-lactide-coglycolide) (PLGA) nanoparticles, followed by sequential coating with O6-BG-grafted chitosan (BG-CS) layers and yeast shell walls (YSW) via layer-by-layer assembly (LBL) process, forming TMZ@P-BG/YSW biohybrids. Due to the yeast cell membrane-camouflage, TMZ@P-BG/YSW particles exhibited significantly enhanced colloidal stability as well as low premature drug leakage in simulated gastrointestinal conditions. In vitro drug release profiles of TMZ@P-BG/YSW particles revealed noticeable higher TMZ release in simulated tumor acidic environment within 72 h. Meanwhile, O6-BG could down-regulate MGMT expression in CT26 colon carcinoma cells, ultimately facilitating TMZ-induced tumor cell death. After oral delivery of yeast cell membrane-camouflaged particles containing fluorescent tracer (Cy5), TMZ@P-BG/YSW and bare YSW displayed high retention time of 12 h in the colon and small intestine (ileum). Correspondingly, oral gavage administration of TMZ@P-BG/YSW particles afforded favorable tumor-specific retention and superior tumor growth inhibition. Overall, TMZ@P-BG/YSW is validated to be a safe, targetable and effective formulation, paving a new avenue towards highly effective and precise treatment of malignancies.
PLGA-based bioinspired platform for tumor-specific retention and enhanced colorectal cancer therapy. [Display omitted] Temozolomide (TMZ) is an oral DNA-alkylating drug used in colorectal cancer (CRC) chemotherapy. In this work, we proposed a safe and biomimetic platform for macrophages-targeted delivery of TMZ and O -benzylguanine (O -BG). TMZ was loaded in poly (D, l-lactide-coglycolide) (PLGA) nanoparticles, followed by sequential coating with O -BG-grafted chitosan (BG-CS) layers and yeast shell walls (YSW) via layer-by-layer assembly (LBL) process, forming TMZ@P-BG/YSW biohybrids. Due to the yeast cell membrane-camouflage, TMZ@P-BG/YSW particles exhibited significantly enhanced colloidal stability as well as low premature drug leakage in simulated gastrointestinal conditions. In vitro drug release profiles of TMZ@P-BG/YSW particles revealed noticeable higher TMZ release in simulated tumor acidic environment within 72 h. Meanwhile, O -BG could down-regulate MGMT expression in CT26 colon carcinoma cells, ultimately facilitating TMZ-induced tumor cell death. After oral delivery of yeast cell membrane-camouflaged particles containing fluorescent tracer (Cy5), TMZ@P-BG/YSW and bare YSW displayed high retention time of 12 h in the colon and small intestine (ileum). Correspondingly, oral gavage administration of TMZ@P-BG/YSW particles afforded favorable tumor-specific retention and superior tumor growth inhibition. Overall, TMZ@P-BG/YSW is validated to be a safe, targetable and effective formulation, paving a new avenue towards highly effective and precise treatment of malignancies. |
| Author | Liu, Wen-Long Chen, Qi-Wen Yu, Jin-Xin Chen, Xiao-Sui Cheng, Yin-Jia Zhang, Ai-Qing Qin, Si-Yong Ma, Yi-Han He, Yu Zhang, Xian-Zheng |
| Author_xml | – sequence: 1 givenname: Yu surname: He fullname: He, Yu organization: Key Laboratory of Analytical Chemistry of the State Ethnic Affairs Commission, School of Chemistry and Materials Science, South-Central Minzu University, Wuhan 430074, People's Republic of China – sequence: 2 givenname: Qi-Wen surname: Chen fullname: Chen, Qi-Wen organization: Key Laboratory of Biomedical Polymers of Ministry of Education and Department of Chemistry Wuhan University, Wuhan 430072, People's Republic of China – sequence: 3 givenname: Jin-Xin surname: Yu fullname: Yu, Jin-Xin organization: Key Laboratory of Analytical Chemistry of the State Ethnic Affairs Commission, School of Chemistry and Materials Science, South-Central Minzu University, Wuhan 430074, People's Republic of China – sequence: 4 givenname: Si-Yong surname: Qin fullname: Qin, Si-Yong organization: Key Laboratory of Analytical Chemistry of the State Ethnic Affairs Commission, School of Chemistry and Materials Science, South-Central Minzu University, Wuhan 430074, People's Republic of China – sequence: 5 givenname: Wen-Long surname: Liu fullname: Liu, Wen-Long organization: Key Laboratory of Analytical Chemistry of the State Ethnic Affairs Commission, School of Chemistry and Materials Science, South-Central Minzu University, Wuhan 430074, People's Republic of China – sequence: 6 givenname: Yi-Han surname: Ma fullname: Ma, Yi-Han organization: Key Laboratory of Analytical Chemistry of the State Ethnic Affairs Commission, School of Chemistry and Materials Science, South-Central Minzu University, Wuhan 430074, People's Republic of China – sequence: 7 givenname: Xiao-Sui surname: Chen fullname: Chen, Xiao-Sui organization: Key Laboratory of Analytical Chemistry of the State Ethnic Affairs Commission, School of Chemistry and Materials Science, South-Central Minzu University, Wuhan 430074, People's Republic of China – sequence: 8 givenname: Ai-Qing surname: Zhang fullname: Zhang, Ai-Qing organization: Key Laboratory of Analytical Chemistry of the State Ethnic Affairs Commission, School of Chemistry and Materials Science, South-Central Minzu University, Wuhan 430074, People's Republic of China – sequence: 9 givenname: Xian-Zheng surname: Zhang fullname: Zhang, Xian-Zheng organization: Key Laboratory of Biomedical Polymers of Ministry of Education and Department of Chemistry Wuhan University, Wuhan 430072, People's Republic of China – sequence: 10 givenname: Yin-Jia surname: Cheng fullname: Cheng, Yin-Jia email: ChengYJ@mail.scuec.edu.cn organization: Key Laboratory of Analytical Chemistry of the State Ethnic Affairs Commission, School of Chemistry and Materials Science, South-Central Minzu University, Wuhan 430074, People's Republic of China |
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| CitedBy_id | crossref_primary_10_1021_accountsmr_4c00116 crossref_primary_10_1016_j_cclet_2024_109657 crossref_primary_10_1016_j_jddst_2024_105812 crossref_primary_10_4155_tde_2023_0027 |
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| Keywords | Colorectal cancer therapy Oral drug delivery system PLGA Temozolomide Tumor-specific accumulation Yeast shell wall |
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| Snippet | Temozolomide (TMZ) is an oral DNA-alkylating drug used in colorectal cancer (CRC) chemotherapy. In this work, we proposed a safe and biomimetic platform for... |
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| SubjectTerms | Colorectal cancer therapy Oral drug delivery system PLGA Temozolomide Tumor-specific accumulation Yeast shell wall |
| Title | Yeast cell membrane-camouflaged PLGA nanoparticle platform for enhanced cancer therapy |
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