Whole-Virion Influenza Vaccine Recalls an Early Burst of High-Affinity Memory B Cell Response through TLR Signaling

• Published in: The Journal of immunology (1950) Vol. 196; no. 10; pp. 4172 - 4184
• Main Authors: Onodera, Taishi, Hosono, Akira, Odagiri, Takato, Tashiro, Masato, Kaminogawa, Shuichi, Okuno, Yoshinobu, Kurosaki, Tomohiro, Ato, Manabu, Kobayashi, Kazuo, Takahashi, Yoshimasa
• Format: Journal Article
• Language: English
• Published: United States 15.05.2016
• Subjects: Animals; Antibodies, Viral - metabolism; Antibody Affinity; B-Lymphocytes - immunology; B-Lymphocytes - transplantation; Cells, Cultured; Humans; Immunity, Humoral; Immunologic Memory; Influenza Vaccines - immunology; Membrane Glycoproteins - genetics; Membrane Glycoproteins - metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; RNA, Viral - immunology; Signal Transduction; T-Lymphocytes, Helper-Inducer - immunology; Toll-Like Receptor 7 - genetics; Toll-Like Receptor 7 - metabolism; Vaccination; Virion - immunology

Inactivated influenza vaccines have two formulations, whole- and split-virion types; however, how differential formulations impact their booster effects remain unknown. In this study, we demonstrate that whole-virion vaccines recall two waves of Ab responses, early T cell–independent (TI) and late T...