Mixed-effects location and scale Tobit joint models for heterogeneous longitudinal data with skewness, detection limits, and measurement errors

• Published in: Statistical methods in medical research Vol. 27; no. 12; p. 3525
• Main Author: Lu, Tao
• Format: Journal Article
• Language: English
• Published: England 01.12.2018
• Subjects: covariate measurement errors; skew-t distribution; mixed-effects location scale models; Bayesian inference; limit of detection; AIDS clinical trial; longitudinal data

The joint modeling of mean and variance for longitudinal data is an active research area. This type of model has the advantage of accounting for heteroscedasticity commonly observed in between and within subject variations. Most of researches focus on improving the estimating efficiency but ignore m...