Distinct mechanisms of mutant huntingtin toxicity in different yeast strains

• Published in: FEMS yeast research Vol. 17; no. 1; p. fow102
• Main Authors: Serpionov, Genrikh V, Alexandrov, Alexander I, Ter-Avanesyan, Michael D
• Format: Journal Article
• Language: English
• Published: England 01.01.2017
• Subjects: Chromosomal Proteins, Non-Histone - metabolism; Humans; Huntingtin Protein - toxicity; Mutant Proteins - toxicity; Peptide Termination Factors - metabolism; Protein Aggregation, Pathological; Saccharomyces cerevisiae Proteins - metabolism; Yeasts - drug effects; huntingtin toxicity; Sup45/eRF1; polyglutamine; yeast; Sup35/eRF3; amyloid cross-seeding

Expansion of polyglutamine stretches in several proteins causes neurodegenerative amyloidoses, including Huntington disease. In yeast, mutant huntingtin (mHtt) with a stretch of 103 glutamine residues (HttQ103) forms toxic aggregates. A range of yeast strains have been used to elucidate the mechanis...