Post-translational regulation of cardiac myosin binding protein-C: A graphical review

• Published in: Cellular signalling Vol. 76; p. 109788
• Main Authors: Main, Alice, Fuller, William, Baillie, George S.
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.12.2020
• Subjects: Animals; Cardiac contractility; Cardiac myosin binding protein C; Carrier Proteins - physiology; Heart Failure - metabolism; Humans; Myocardium - cytology; Myocardium - metabolism; Myocardium - pathology; Posttranslational modification; Protein Binding; Protein Processing, Post-Translational; Sarcomeres - metabolism; Posttranslational modification; Cardiac contractility; Cardiac myosin binding protein C

Cardiac myosin binding protein-C (cMyBP-C) is a fundamental component of the cardiac sarcomere involved in regulating systolic and diastolic activity, processes which must be tightly maintained to preserve cardiac function. Importantly, as a non-enzymatic protein, cMyBP-C relies solely on post-trans...