Tumor autophagy is associated with survival outcomes in patients with resected non-small cell lung cancer

• Published in: Lung cancer (Amsterdam, Netherlands) Vol. 129; pp. 85 - 91
• Main Authors: Überall, Ivo, Gachechiladze, Mariam, Joerger, Markus, Anděl, Josef, Smičková, Petra, Kolek, Vítězslav, Grygárková, Ivona, Škarda, Josef
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.03.2019
• Subjects: Autophagy; Biomarkers, Tumor - metabolism; Carcinoma, Non-Small-Cell Lung - immunology; Carcinoma, Non-Small-Cell Lung - mortality; Cutoff finder; Disease free survival; Female; Humans; Immunohistochemistry; KM plotter; LC3A; Lung Neoplasms - immunology; Lung Neoplasms - mortality; Male; Microtubule-Associated Proteins - genetics; Microtubule-Associated Proteins - metabolism; Neoplasm Staging; Non-small cell lung cancer; Overall survival; Pneumonectomy; Prognosis; RNA, Messenger - genetics; Stone-like structures; Survival Analysis; Tissue Array Analysis; Prognosis; NSCLC; OS; LC3A; Stone-like structures; HCC; LCC; ER; SCC; KM plotter; Non-small cell lung cancer; Cutoff finder; Atg8; PFS; Overall survival; Disease free survival; SLSs; WHO

•The importance of autophagy in non-small cell lung cancer (NSCLC).•Increased number of stone like structures (SLSs), detected by LC3A immunohistochemistry is associated with poor overall and disease free survival outcomes in patients with NSCLC.•LC3A mRNA expression is also a negative prognostic ma...