A study of the impact of excipient shielding on initial drug release using UV imaging

• Published in: International journal of pharmaceutics Vol. 553; no. 1-2; pp. 229 - 237
• Main Authors: Hiew, Tze Ning, Alaudin, Muhammad Ismail Bin, Chua, Siang Meng, Heng, Paul Wan Sia
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 20.12.2018
• Subjects: Aspirin - administration & dosage; Aspirin - chemistry; Chemistry, Pharmaceutical - methods; Drug Compounding - methods; Drug Liberation; Excipient shielding; Excipients - chemistry; Hydrophobic and Hydrophilic Interactions; Initial dissolution; Particle Size; Raman mapping; Solubility; Spectrum Analysis, Raman; Surface dissolution; Ultraviolet Rays; UV imaging; Surface dissolution; UV imaging; Raman mapping; Excipient shielding; Initial dissolution

[Display omitted] Knowledge on the dissolution behaviour of a drug is critical for efficient and effective product development. As the drug has almost always to be formulated with excipients in the design of a dosage form, it is important to examine the implications of the choice of excipients on th...