An approach for predicting the true density of powders based on in-die compression data

• Published in: International journal of pharmaceutics Vol. 637; p. 122875
• Main Authors: Elsergany, Ramy N., Vreeman, Gerrit, Sun, Changquan Calvin
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 25.04.2023
• Subjects: Helium; Helium pycnometry; In-die Py; Powders; Pressure; Stress transmission coefficient; Tablets - chemistry; True density; Water-containing materials; In-die Py; True density; Helium pycnometry; Water-containing materials; Stress transmission coefficient

[Display omitted] Helium pycnometry, a commonly used technique for measuring the true density of powders, is sensitive to the release of volatiles during measurement. This can lead to over-estimated true density, and as such, an accurate method for determining the true density of powders containing...