HPV18 E1 Protein Plus α -Galactosylceramide Elicit in Mice CD8 + T Cell Cross-Reactivity Against Cells Expressing E1 from Diverse Human Papillomavirus Types

• Published in: Viral immunology Vol. 32; no. 6; p. 269
• Main Authors: Amador-Molina, Alfredo, Amador-Molina, Juan C, Arciniega, Juan L, Lizano, Marcela
• Format: Journal Article
• Language: English
• Published: United States 01.07.2019
• Subjects: E1 protein; galactosylceramide; cross-reactivity; human papillomavirus; CD8 T cells

CD8 T cell immune response plays a critical role in the clearance of human papillomavirus (HPV)-infected cells. During the natural history of HPV infection, the E1 protein, an early-expressed helicase highly conserved among papillomaviruses, is involved in the replication of HPV genomes. We have pre...