GC–MS Quantification Method for Mephedrone in Plasma and Urine: Application to Human Pharmacokinetics

• Published in: Journal of analytical toxicology Vol. 41; no. 2; p. 100
• Main Authors: Olesti, Eulàlia, Pujadas, Mitona, Papaseit, Esther, Pérez-Mañá, Clara, Pozo, Óscar J., Farré, Magí, de la Torre, Rafael
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.03.2017
• Subjects: Administration, Oral; Calibration; Central Nervous System Stimulants - administration & dosage; Central Nervous System Stimulants - blood; Central Nervous System Stimulants - urine; Cross-Over Studies; Double-Blind Method; Efecte dels medicaments; Gas Chromatography-Mass Spectrometry - instrumentation; Gas Chromatography-Mass Spectrometry - methods; Half-Life; Healthy Volunteers; Humans; Limit of Detection; Male; Methamphetamine - administration & dosage; Methamphetamine - analogs & derivatives; Methamphetamine - blood; Methamphetamine - urine; Pilot Projects; Reproducibility of Results; Sistema nerviós central; Substance Abuse Detection - instrumentation; Substance Abuse Detection - methods

Increasing consumption has been observed among young people of new psychoactive substances, including synthetic cathinone derivatives. The most well known of these is mephedrone whose use has been related to acute intoxication and fatality. Several methods able to detect mephedrone have been reporte...