Development and characterisation of novel poly (vinyl alcohol)/poly (vinyl pyrrolidone)-based hydrogel-forming microneedle arrays for enhanced and sustained transdermal delivery of methotrexate

• Published in: International journal of pharmaceutics Vol. 586; p. 119580
• Main Authors: Tekko, Ismaiel A., Chen, Gaoyun, Domínguez-Robles, Juan, Thakur, Raghu Raj Singh, Hamdan, Iman M.N., Vora, Lalitkumar, Larrañeta, Eneko, McElnay, James C., McCarthy, Helen O., Rooney, Madeleine, Donnelly, Ryan F.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 30.08.2020
• Subjects: Administration, Cutaneous; Animals; Antirheumatic Agents - administration & dosage; Antirheumatic Agents - pharmacokinetics; Antirheumatic Agents - toxicity; Chemistry, Pharmaceutical; Crosslinking; Delayed-Action Preparations; Drug Carriers - chemistry; Drug Delivery Systems; Female; Hydrogel-forming microneedles; Hydrogels; Juvenile idiopathic arthritis; Methotrexate; Methotrexate - administration & dosage; Methotrexate - pharmacokinetics; Methotrexate - toxicity; Needles; Polyvinyl Alcohol - chemistry; Povidone - chemistry; Rats; Rats, Sprague-Dawley; Skin Absorption; Sustained release; Swine; Transdermal delivery; Transdermal Patch; Transdermal delivery; Crosslinking; Sustained release; Methotrexate; Juvenile idiopathic arthritis; Hydrogel-forming microneedles
• ISSN: 0378-5173; 1873-3476; 1873-3476
• DOI: 10.1016/j.ijpharm.2020.119580

[Display omitted] •Novel hydrogel-forming microneedles were produced.•Their physicochemical properties were promising.•Methotrexate was successfully delivered in vitro and in vivo. Methotrexate (MTX) is one of the mainstays of treatment for rheumatoid arthritis (RA) and juvenile idiopathic arthritis...