Long-term Effect of a Single Subcritical Knee Injury: Increasing the Risk of Anterior Cruciate Ligament Rupture and Osteoarthritis

• Published in: The American journal of sports medicine Vol. 49; no. 2; p. 391
• Main Authors: Blaker, Carina L, Zaki, Sanaa, Little, Christopher B, Clarke, Elizabeth C
• Format: Journal Article
• Language: English
• Published: United States 01.02.2021
• Subjects: Animals; Anterior Cruciate Ligament - physiopathology; Anterior Cruciate Ligament Injuries - etiology; Knee Injuries - complications; Knee Joint; Male; Mice; Mice, Inbred C57BL; Osteoarthritis, Knee - etiology; Rupture; articular cartilage; knee; ACL; biomechanics of ligament; animal model; microscopic pathology

Rupture of the anterior cruciate ligament (ACL) is a well-known risk factor for the development of posttraumatic osteoarthritis (PTOA), but patients with the "same injury" can have vastly different trajectories for the onset and progression of disease. Minor subcritical injuries preceding...