Cytotoxicity and anti-inflammatory effects of root bark extracts of Acanthopanax henryi

• Published in: Chinese journal of natural medicines Vol. 12; no. 2; pp. 121 - 125
• Main Authors: KIM, Jong-Hwan, LIU, Xiang-Qian, DAI, Ling, YOOK, Chang-Soo, LEE, Kyung-Tae
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.02.2014
• Subjects: Acanthopanax henryi (Oliv.) Harms; Animals; Anti-inflammatory activity; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Cytotoxic activity; Dinoprostone - metabolism; Dose-Response Relationship, Drug; Eleutherococcus; Inflammation - chemically induced; Inflammation - drug therapy; Inflammation - metabolism; Interleukin-1beta - metabolism; Interleukin-6 - metabolism; Lipopolysaccharides; Macrophages - drug effects; Macrophages - metabolism; Mice; Nitric Oxide - metabolism; Nitric Oxide Synthase Type II - metabolism; Phytotherapy; Plant Bark; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Plant Roots; Root bark extract; Anti-inflammatory activity; Root bark extract; Acanthopanax henryi (Oliv.) Harms; Cytotoxic activity

To investigate the cytotoxicity, anti-inflammatory activity, and action mechanism of root bark extracts of Acanthopanax henryi. The hot methanol extract of the root bark of A. henryi was subjected to XAD-4 column chromatography eluting with a gradient of methanol in water. The cytotoxicity and anti-...