Pharmacokinetic-pharmacodynamic Modelling of NH600001 in Healthy Subjects and Patients Undergoing Gastroscopy

• Published in: The AAPS journal Vol. 27; no. 1; p. 21
• Main Authors: Liu, Yaxin, Kuang, Yun, Huang, Jie, Jiang, Dan, Cao, Yajie, Gao, Qi, Li, Zifeng, Ouyang, Wen, Wang, Saiying, Pei, Qi, Yang, Guoping
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 21.12.2024; Springer
• Subjects: Adult; Aged; Alfentanil; Alfentanil - administration & dosage; Alfentanil - pharmacokinetics; Alfentanil - pharmacology; Biochemistry; Biomedical and Life Sciences; Biomedicine; Biotechnology; Body weight; Ethylenediaminetetraacetic acid; Etomidate; Female; Gastroscopy; Healthy Volunteers; Humans; Hypnotics and Sedatives - administration & dosage; Hypnotics and Sedatives - pharmacokinetics; Hypnotics and Sedatives - pharmacology; Male; Medical research; Medicine, Experimental; Middle Aged; Models, Biological; Pharmacology/Toxicology; Pharmacy; Research Article; Young Adult; population pharmacokinetic/pharmacodynamic modelling; gastroscopic sedation; general anaesthetic drugs; model-informed drug development
• ISSN: 1550-7416; 1550-7416
• DOI: 10.1208/s12248-024-01004-7

NH600001 is a new general anaesthetic drug with a structure similar to etomidate. The objective of this study was to investigate the relationship between concentrations of NH600001 and sedation efficacy based on data from phase I-II studies and factors influencing the pharmacokinetics and pharmacody...