α-Helical cell-penetrating peptide-mediated nasal delivery of resveratrol for inhibition of epithelial-to-mesenchymal transition

• Published in: Journal of controlled release Vol. 317; pp. 181 - 194
• Main Authors: Kim, Yumin, Hwang, Soyoung, Khalmuratova, Roza, Kang, Sunah, Lee, Mingyu, Song, Youngjun, Park, Jong-Wan, Yu, Jaehoon, Shin, Hyun-Woo, Lee, Yan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 10.01.2020
• Subjects: Cell-penetrating peptide; Chronic rhinosinusitis; Epithelial-to-mesenchymal transition; Intranasal delivery; Resveratrol; Chronic rhinosinusitis; Intranasal delivery; Epithelial-to-mesenchymal transition; Resveratrol; Cell-penetrating peptide

In the present study, we examined the potential of cell-penetrating peptide (CPP)-based intranasal drug delivery for the treatment of localized nasal diseases. Many charged or non-hydrophobic drugs have difficulty penetrating into the nasal epithelium due to intrinsic membrane impermeability and rap...