Toll-like receptor 4 prevents AOM/DSS-induced colitis-associated colorectal cancer in Bacteroides fragilis gnotobiotic mice

• Published in: Human & experimental toxicology Vol. 40; no. 4; pp. 622 - 633
• Main Authors: Lee, Yen-Peng, Huang, Wen-Ching, Lin, Tien-Jen, Chiu, Chien-Chao, Wang, Yu-Chih, Chen, Yi-Hsun, Hung, Shao-Wen, Chuang, Hsiao-Li, Chen, Ter-Hsin
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.04.2021; Sage Publications Ltd
• Subjects: Animal models; Animals; Azoxymethane; Bacteroides fragilis; beta Catenin - metabolism; Cancer; Cell proliferation; Colitis; Colitis - chemically induced; Colitis - metabolism; Colitis - microbiology; Colitis - pathology; Colitis-Associated Neoplasms - metabolism; Colitis-Associated Neoplasms - microbiology; Colitis-Associated Neoplasms - pathology; Colon - metabolism; Colon - microbiology; Colon - pathology; Colonization; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - etiology; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - microbiology; Colorectal Neoplasms - pathology; Cyclooxygenase 2 - metabolism; Dextran; Dextran Sulfate; Dextrans; Disease Models, Animal; Germ-Free Life; Germfree; Gnotobiotic; Immune system; Immunohistochemistry; Inflammation; Inflammatory bowel disease; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase Type II - metabolism; Nitric-oxide synthase; Proliferating cell nuclear antigen; Proliferating Cell Nuclear Antigen - metabolism; Receptors; TLR4 protein; Toll-Like Receptor 4 - genetics; Toll-like receptors; Tumors; β-Catenin; gnotobiotic; mono-colonization; Bacteroides fragilis; colitis-associated colorectal cancer; Toll-like receptor 4

Bacteroides fragilis (BF) plays a critical role in developing and maintaining the mammalian immune system. We previously found that BF colonization could prevent inflammation and tumor formation in a germ-free (GF) colitis-associated colorectal cancer (CAC) mouse model. The role of Toll-like recepto...