Enhanced skin delivery of quercetin by microemulsion

For topical application of quercetin it is necessary to improve the low efficiency of its intradermal delivery as well as its low solubility in aqueous and organic vesicles. The aim of this study was to determine the usefulness of a microemulsion for that purpose. A microemulsion consisting of isopr...

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Published inJournal of pharmacy and pharmacology Vol. 61; no. 7; p. 855
Main Authors Kitagawa, Shuji, Tanaka, Yuko, Tanaka, Manami, Endo, Kanako, Yoshii, Akiko
Format Journal Article
LanguageEnglish
Published England 01.07.2009
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Abstract For topical application of quercetin it is necessary to improve the low efficiency of its intradermal delivery as well as its low solubility in aqueous and organic vesicles. The aim of this study was to determine the usefulness of a microemulsion for that purpose. A microemulsion consisting of isopropyl myristate, 150 mM NaCl solution, Tween 80 and ethanol was prepared. The skin delivery of quercetin by microemulsion using excised guinea-pig and Yucatan micropig skin in Franz diffusion cells was examined. Lipid peroxidation in skin was also tested using iron(II) and citrate. Using a w/o microemulsion as a vehicle, intradermal delivery of quercetin was significantly increased, as was its solubility. Quercetin penetrated deep into the skin, but no transfer was observed into the receptor compartment. It was confirmed that quercetin retained in the skin dose-dependently inhibited lipid peroxidation. The findings indicate the potential use of microemulsions for the skin delivery of quercetin, where it exerts antioxidative effects.
AbstractList For topical application of quercetin it is necessary to improve the low efficiency of its intradermal delivery as well as its low solubility in aqueous and organic vesicles. The aim of this study was to determine the usefulness of a microemulsion for that purpose. A microemulsion consisting of isopropyl myristate, 150 mM NaCl solution, Tween 80 and ethanol was prepared. The skin delivery of quercetin by microemulsion using excised guinea-pig and Yucatan micropig skin in Franz diffusion cells was examined. Lipid peroxidation in skin was also tested using iron(II) and citrate. Using a w/o microemulsion as a vehicle, intradermal delivery of quercetin was significantly increased, as was its solubility. Quercetin penetrated deep into the skin, but no transfer was observed into the receptor compartment. It was confirmed that quercetin retained in the skin dose-dependently inhibited lipid peroxidation. The findings indicate the potential use of microemulsions for the skin delivery of quercetin, where it exerts antioxidative effects.
Author Tanaka, Yuko
Yoshii, Akiko
Kitagawa, Shuji
Endo, Kanako
Tanaka, Manami
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Snippet For topical application of quercetin it is necessary to improve the low efficiency of its intradermal delivery as well as its low solubility in aqueous and...
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StartPage 855
SubjectTerms Administration, Cutaneous
Animals
Antioxidants - administration & dosage
Antioxidants - pharmacokinetics
Drug Delivery Systems
Emulsions
Guinea Pigs
In Vitro Techniques
Lipid Peroxidation
Male
Permeability
Quercetin - administration & dosage
Quercetin - pharmacokinetics
Skin - metabolism
Skin Absorption
Solubility
Swine
Swine, Miniature
Title Enhanced skin delivery of quercetin by microemulsion
URI https://www.ncbi.nlm.nih.gov/pubmed/19589226
Volume 61
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