E6 Protein Expressed by High-Risk HPV Activates Super-Enhancers of the EGFR and c-MET Oncogenes by Destabilizing the Histone Demethylase KDM5C

• Published in: Cancer research (Chicago, Ill.) Vol. 78; no. 6; pp. 1418 - 1430
• Main Authors: Chen, Xiaohua, Loo, Jun Xian, Shi, Xin, Xiong, Wenjun, Guo, Yong, Ke, Haiqiang, Yang, Mingkun, Jiang, Yanping, Xia, Siyu, Zhao, Min, Zhong, Shan, He, Chunjiang, Fu, Li, Li, Feng
• Format: Journal Article
• Language: English
• Published: United States American Association for Cancer Research, Inc 15.03.2018
• Subjects: Animals; Anogenital; c-Met protein; Cancer; Cell Line, Tumor; Cell lines; Cervical cancer; Dysplasia; E6 protein; Enhancer Elements, Genetic; Enhancers; Epidermal growth factor receptors; Epigenetics; ErbB Receptors - genetics; ErbB Receptors - metabolism; Female; Gene Expression Regulation, Neoplastic; Genomes; Head & neck cancer; Head and neck; Histone Demethylases - genetics; Histone Demethylases - metabolism; Host-Pathogen Interactions - genetics; Human papillomavirus; Human papillomavirus 16 - pathogenicity; Humans; Isotypes; Mice, Nude; Neck; Oncogene Proteins, Viral - genetics; Oncogene Proteins, Viral - metabolism; p53 Protein; Papillomaviridae; Papillomavirus Infections - genetics; Papillomavirus Infections - metabolism; Proteasomes; Protein Stability; Proteins; Proto-Oncogene Proteins c-met - genetics; Proto-Oncogene Proteins c-met - metabolism; Proto-oncogenes; Repressor Proteins - genetics; Repressor Proteins - metabolism; Ribonucleic acid; Risk groups; RNA; Telomerase; Transcription; Tumor cell lines; Tumorigenicity; Ubiquitin-protein ligase; Ubiquitination; Uterine Cervical Neoplasms - genetics; Uterine Cervical Neoplasms - metabolism; Uterine Cervical Neoplasms - virology

The high-risk (HR) human papillomaviruses (HPV) are causative agents of anogenital tract dysplasia and cancers and a fraction of head and neck cancers. The HR HPV E6 oncoprotein possesses canonical oncogenic functions, such as p53 degradation and telomerase activation. It is also capable of stimulat...