E6 Protein Expressed by High-Risk HPV Activates Super-Enhancers of the EGFR and c-MET Oncogenes by Destabilizing the Histone Demethylase KDM5C - Chen, Xiaohua; Loo, Jun Xian; Shi, Xin; Xiong, Wenjun; Guo, Yong; Ke, Haiqiang; Yang, Mingkun; Jiang, Yanping; Xia, Siyu; Zhao, Min; Zhong, Shan; He, Chunjiang; et al. (Cancer research (Chicago, Ill.), 2018)
Keywords: Animals; Anogenital; c-Met protein; Cancer; Cell Line, Tumor; Cell lines; Cervical cancer; Dysplasia; E6 protein; Enhancer Elements, Genetic; Enhancers; Epidermal growth factor receptors; Epigenetics; ErbB Receptors - genetics; ErbB Receptors - metabolism; Female; Gene Expression Regulation, Neoplastic; Genomes; Head & neck cancer; Head and neck; Histone Demethylases - genetics; Histone Demethylases - metabolism; Host-Pathogen Interactions - genetics; Human papillomavirus; Human papillomavirus 16 - pathogenicity; Humans; Isotypes; Mice, Nude; Neck; Oncogene Proteins, Viral - genetics; Oncogene Proteins, Viral - metabolism; p53 Protein; Papillomaviridae; Papillomavirus Infections - genetics; Papillomavirus Infections - metabolism; Proteasomes; Protein Stability; Proteins; Proto-Oncogene Proteins c-met - genetics; Proto-Oncogene Proteins c-met - metabolism; Proto-oncogenes; Repressor Proteins - genetics; Repressor Proteins - metabolism; Ribonucleic acid; Risk groups; RNA; Telomerase; Transcription; Tumor cell lines; Tumorigenicity; Ubiquitin-protein ligase; Ubiquitination; Uterine Cervical Neoplasms - genetics; Uterine Cervical Neoplasms - metabolism; Uterine Cervical Neoplasms - virology