Protective role of chrysin on doxorubicin‐induced oxidative stress and DNA damage in rat testes

• Published in: Andrologia Vol. 52; no. 9; pp. e13747 - n/a
• Main Authors: Belhan, Saadet, Özkaraca, Mustafa, Özdek, Uğur, Kömüroğlu, Ahmet Ufuk
• Format: Journal Article
• Language: English
• Published: Berlin Wiley Subscription Services, Inc 01.10.2020
• Subjects: Biopsy; Catalase; chrysin; Deoxyguanosine; Deoxyribonucleic acid; DNA; DNA damage; Doxorubicin; Glutathione; Immunofluorescence; Malondialdehyde; Oxidative stress; Sperm; spermatozoa; Testes; Testicular DNA damage; Testosterone; Tubules

This study investigated the role of chrysin (CR) in DNA damage likely to occur in the testicle and oxidative stress caused by doxorubicin (DXR). Twenty‐eight rats were divided into four groups as control, DXR, DXR + CR and CR groups. Sperm parameters, oxidative status, testicular biopsy score, DNA d...