Lipid metabolism and cancer

Dysregulation in lipid metabolism is among the most prominent metabolic alterations in cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological membranes, and signaling molecules needed for proliferation, survival, invasion, metastasis, and response to the tumor micr...

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Published inThe Journal of experimental medicine Vol. 218; no. 1
Main Authors Bian, Xueli, Liu, Rui, Meng, Ying, Xing, Dongming, Xu, Daqian, Lu, Zhimin
Format Journal Article
LanguageEnglish
Published United States Rockefeller University Press 04.01.2021
SeriesCancer Focus
Subjects
Cancer Focus
Metabolism
Review
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Summary:Dysregulation in lipid metabolism is among the most prominent metabolic alterations in cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological membranes, and signaling molecules needed for proliferation, survival, invasion, metastasis, and response to the tumor microenvironment impact and cancer therapy. Here, we summarize and discuss current knowledge about the advances made in understanding the regulation of lipid metabolism in cancer cells and introduce different approaches that have been clinically used to disrupt lipid metabolism in cancer therapy.
Bibliography:ObjectType-Article-1
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X. Bian, R. Liu, and Y. Meng contributed equally to this paper.
Disclosures: The authors declare no competing interests exist.
ISSN:0022-1007
1540-9538
1540-9538
DOI:10.1084/jem.20201606