Lipid metabolism and cancer
Dysregulation in lipid metabolism is among the most prominent metabolic alterations in cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological membranes, and signaling molecules needed for proliferation, survival, invasion, metastasis, and response to the tumor micr...
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| Published in | The Journal of experimental medicine Vol. 218; no. 1 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Rockefeller University Press
04.01.2021
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| Series | Cancer Focus |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Dysregulation in lipid metabolism is among the most prominent metabolic alterations in cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological membranes, and signaling molecules needed for proliferation, survival, invasion, metastasis, and response to the tumor microenvironment impact and cancer therapy. Here, we summarize and discuss current knowledge about the advances made in understanding the regulation of lipid metabolism in cancer cells and introduce different approaches that have been clinically used to disrupt lipid metabolism in cancer therapy. |
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| AbstractList | Dysregulation in lipid metabolism is among the most prominent metabolic alterations in cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological membranes, and signaling molecules needed for proliferation, survival, invasion, metastasis, and response to the tumor microenvironment impact and cancer therapy. Here, we summarize and discuss current knowledge about the advances made in understanding the regulation of lipid metabolism in cancer cells and introduce different approaches that have been clinically used to disrupt lipid metabolism in cancer therapy. Dysregulation in lipid metabolism is among the most prominent metabolic alterations in cancer. This review discusses current knowledge about the advances in understanding lipid metabolism regulation in cancer cells and introduces therapies that disrupt lipid metabolism for cancer treatment. Dysregulation in lipid metabolism is among the most prominent metabolic alterations in cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological membranes, and signaling molecules needed for proliferation, survival, invasion, metastasis, and response to the tumor microenvironment impact and cancer therapy. Here, we summarize and discuss current knowledge about the advances made in understanding the regulation of lipid metabolism in cancer cells and introduce different approaches that have been clinically used to disrupt lipid metabolism in cancer therapy. Dysregulation in lipid metabolism is among the most prominent metabolic alterations in cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological membranes, and signaling molecules needed for proliferation, survival, invasion, metastasis, and response to the tumor microenvironment impact and cancer therapy. Here, we summarize and discuss current knowledge about the advances made in understanding the regulation of lipid metabolism in cancer cells and introduce different approaches that have been clinically used to disrupt lipid metabolism in cancer therapy.Dysregulation in lipid metabolism is among the most prominent metabolic alterations in cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological membranes, and signaling molecules needed for proliferation, survival, invasion, metastasis, and response to the tumor microenvironment impact and cancer therapy. Here, we summarize and discuss current knowledge about the advances made in understanding the regulation of lipid metabolism in cancer cells and introduce different approaches that have been clinically used to disrupt lipid metabolism in cancer therapy. |
| Author | Liu, Rui Meng, Ying Lu, Zhimin Xu, Daqian Bian, Xueli Xing, Dongming |
| AuthorAffiliation | 3 Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China 1 Cancer Institute of The Affiliated Hospital of Qingdao University and Qingdao Cancer Institute, Qingdao, China 2 State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, China 5 Zhejiang University Cancer Center, Hangzhou, China 4 School of Life Sciences, Tsinghua University, Beijing, China |
| AuthorAffiliation_xml | – name: 4 School of Life Sciences, Tsinghua University, Beijing, China – name: 1 Cancer Institute of The Affiliated Hospital of Qingdao University and Qingdao Cancer Institute, Qingdao, China – name: 5 Zhejiang University Cancer Center, Hangzhou, China – name: 2 State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, China – name: 3 Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China |
| Author_xml | – sequence: 1 givenname: Xueli orcidid: 0000-0001-9940-8396 surname: Bian fullname: Bian, Xueli – sequence: 2 givenname: Rui orcidid: 0000-0001-8757-3159 surname: Liu fullname: Liu, Rui – sequence: 3 givenname: Ying orcidid: 0000-0002-1165-9009 surname: Meng fullname: Meng, Ying – sequence: 4 givenname: Dongming orcidid: 0000-0002-2359-0440 surname: Xing fullname: Xing, Dongming – sequence: 5 givenname: Daqian orcidid: 0000-0003-0478-2997 surname: Xu fullname: Xu, Daqian – sequence: 6 givenname: Zhimin orcidid: 0000-0002-2859-2736 surname: Lu fullname: Lu, Zhimin |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33601415$$D View this record in MEDLINE/PubMed |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 X. Bian, R. Liu, and Y. Meng contributed equally to this paper. Disclosures: The authors declare no competing interests exist. |
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| Publisher | Rockefeller University Press |
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