The TNF/IL‐23/IL‐17 axis—Head‐to‐head trials comparing different biologics in psoriasis treatment

• Published in: Scandinavian journal of immunology Vol. 92; no. 4; pp. e12946 - n/a
• Main Authors: ten Bergen, Lisa Lynn, Petrovic, Aleksandra, Krogh Aarebrot, Anders, Appel, Silke
• Format: Journal Article
• Language: English
• Published: Oxford Wiley Subscription Services, Inc 01.10.2020
• Subjects: Biological products; biologics; Cell differentiation; Cytokines; Drug development; head‐to‐head trials; Immunopathogenesis; Inflammation; Lymphocytes T; Oral administration; Psoriasis; Psoriasis vulgaris; TNF/IL‐23/IL‐17 axis; Tumor necrosis factor

Psoriasis is a T cell–mediated disease with autoimmune characteristics modulated by genetic susceptibility along with environmental triggers. Inflammatory pathways marked with excessive production of cytokines IL‐12 and IL‐23, drive differentiation of pathogenic T cell responses resulting in TNF and...