Single‐cell RNA sequencing reveals the epithelial cell heterogeneity and invasive subpopulation in human bladder cancer

• Published in: International journal of cancer Vol. 149; no. 12; pp. 2099 - 2115
• Main Authors: Lai, Huadong, Cheng, Xiaomu, Liu, Qiang, Luo, Wenqin, Liu, Mengyao, Zhang, Man, Miao, Juju, Ji, Zhongzhong, Lin, Guan Ning, Song, Weichen, Zhang, Lianhua, Bo, Juanjie, Yang, Guoliang, Wang, Jia, Gao, Wei‐Qiang
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 15.12.2021; Wiley Subscription Services, Inc
• Subjects: Basal cells; Bladder cancer; Cancer; Epithelial cells; intratumoral heterogeneity; Invasiveness; Lamina propria; Medical research; Mesenchyme; Phenotypes; single‐cell RNA sequencing; Sox9 protein; Stem cells; Transcription; Tumor cells; tumor cells communication; tumor invasion

Bladder cancer represents a highly heterogeneous disease characterized by distinct histological, molecular and clinical phenotypes, and a detailed analysis of tumor cell invasion and crosstalks within bladder tumor cells has not been determined. Here, we applied droplet‐based single‐cell RNA sequenc...