The expanded clinical spectrum of anti-GABABR encephalitis and added value of KCTD16 autoantibodies

• Published in: Brain (London, England : 1878) Vol. 142; no. 6; pp. 1631 - 1643
• Main Authors: van Coevorden-Hameete, Marleen H, de Bruijn, Marienke A A M, de Graaff, Esther, Bastiaansen, Danielle A E M, Schreurs, Marco W J, Demmers, Jeroen A A, Ramberger, Melanie, Hulsenboom, Esther S P, Nagtzaam, Mariska M P, Boukhrissi, Sanae, Veldink, Jan H, Verschuuren, Jan J G M, Hoogenraad, Casper C, Sillevis Smitt, Peter A E, Titulaer, Maarten J
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.06.2019
• Subjects: Adult; Aged; Aged, 80 and over; Autoantibodies - immunology; Encephalitis - diagnosis; Encephalitis - genetics; Female; gamma-Aminobutyric Acid - genetics; gamma-Aminobutyric Acid - immunology; Humans; Immunologic Factors; Intracellular Signaling Peptides and Proteins - genetics; Intracellular Signaling Peptides and Proteins - immunology; Male; Middle Aged; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - immunology; Neurons - pathology; Original; Seizures - diagnosis; Seizures - genetics; Status Epilepticus - genetics; Status Epilepticus - immunology; autoimmune encephalitis; antineuronal autoantibodies; neuronal surface antigens; paraneoplastic neurological disorders
• ISSN: 0006-8950; 1460-2156; 1460-2156
• DOI: 10.1093/brain/awz094

In this study we report the clinical features of 32 patients with gamma aminobutyric acid B receptor (GABABR) antibodies, identify additional autoantibodies in patients with anti-GABABR encephalitis that mark the presence of an underlying small cell lung carcinoma and optimize laboratory methods for...