The Comorbid Association of Migraine with Osteoarthritis and Hypertension Complement C3F and Berkson's Bias

• Published in: Cephalalgia Vol. 17; no. 1; pp. 23 - 26
• Main Authors: Peroutka, SJ, Price, SC, Jones, KW
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.02.1997; Blackwell Science Ltd
• Subjects: Comorbidity; Complement C3c - genetics; Coronary Disease - complications; Coronary Disease - epidemiology; Coronary Disease - genetics; Genotype; Humans; Hypertension - complications; Hypertension - epidemiology; Hypertension - genetics; Migraine Disorders - complications; Migraine Disorders - epidemiology; Migraine Disorders - genetics; Osteoarthritis - complications; Osteoarthritis - epidemiology; Osteoarthritis - genetics; Polymorphism, Genetic

Migraine is known to have a major genetic component and has been associated with a wide variety of comorbid disorders including arthritis and heart disease. Since migraine and some of its comorbid disorders involve inflammation, complement C3, a protein involved in acute inflammation, was selected f...