Pathophysiological mechanisms of impaired limb use and repair strategies for motor systems after unilateral injury of the developing brain

• Published in: Developmental medicine and child neurology Vol. 55; no. s4; pp. 27 - 31
• Main Authors: Friel, Kathleen M, Chakrabarty, Samit, Martin, John H
• Format: Journal Article
• Language: English
• Published: England 01.11.2013
• Subjects: Cerebral Palsy - complications; Cerebral Palsy - physiopathology; Cerebral Palsy - therapy; Extremities - physiology; Humans; Infant; Motor Skills Disorders - etiology; Motor Skills Disorders - physiopathology; Motor Skills Disorders - therapy; Neuronal Plasticity - physiology; Prenatal Injuries - etiology; Prenatal Injuries - physiopathology; Prenatal Injuries - therapy; Pyramidal Tracts - physiopathology

The corticospinal tract (CST) is important for limb control. In humans, it begins developing prenatally but CST connections do not have a mature pattern until about 6 months of age and its capacity to evoke muscle contraction does not mature until mid‐adolescence. An initially bilateral projection i...