Mitochondria transfer from early stages of erythroblasts to their macrophage niche via tunnelling nanotubes

Summary Adult erythropoiesis entails a series of well‐coordinated events that produce mature red blood cells. One of such events is the mitochondria clearance that occurs cell‐autonomously via autophagy‐dependent mechanisms. Interestingly, recent studies have shown mitochondria transfer activities b...

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Published inBritish journal of haematology Vol. 193; no. 6; pp. 1260 - 1274
Main Authors Yang, Chong, Endoh, Mitsuhiro, Tan, Darren Q., Nakamura‐Ishizu, Ayako, Takihara, Yuji, Matsumura, Takayoshi, Suda, Toshio
Format Journal Article
LanguageEnglish
Published Oxford Blackwell Publishing Ltd 01.06.2021
Subjects
Actin
Autophagy
Cell differentiation
erythroblastic island
Erythroblasts
Erythrocytes
Erythroid cells
Erythropoiesis
Filamentation
F‐actin filamentation
Hematology
Macrophages
Mitochondria
mitochondria transfer
Nanotubes
Phagocytosis
tunnelling nanotubes
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Summary:Summary Adult erythropoiesis entails a series of well‐coordinated events that produce mature red blood cells. One of such events is the mitochondria clearance that occurs cell‐autonomously via autophagy‐dependent mechanisms. Interestingly, recent studies have shown mitochondria transfer activities between various cell types. In the context of erythropoiesis, macrophages are known to interact closely with the early stages of erythroblasts to provide a specialized niche, termed erythroblastic islands (EBI). However, whether mitochondria transfer can occur in the EBI niche has not been explored. Here, we report that mitochondria transfer in the EBI niche occurs in vivo. We observed mitochondria transfer activities from the early stages of erythroblasts to macrophages in the reconstituted in vitro murine EBI via different modes, including tunnelling nanotubes (TNT). Moreover, we demonstrated that Wiskott‐Aldrich syndrome protein (WASp) in macrophages mediates TNT formation and mitochondria transfer via the modulation of F‐actin filamentation, thus promoting mitochondria clearance from erythroid cells, to potentially enhance their differentiation. Taken together, our findings provide novel insight into the mitochondria clearance machineries that mediate erythroid maturation.
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ISSN:0007-1048
1365-2141
DOI:10.1111/bjh.17531