2‐Mercaptonicotinoyl glycine prevents UV‐induced skin darkening and delayed tanning in healthy subjects: A randomized controlled clinical study

• Published in: Journal of cosmetic dermatology Vol. 23; no. 5; pp. 1745 - 1752
• Main Authors: Dormael, R., Sextius, P., Bourokba, N., Mainguene, E., Tachon, R., Gaurav, K., Jouni, H., Bastien, P., Diridollou, S.
• Format: Journal Article
• Language: English
• Published: England 01.05.2024
• Subjects: Adult; anti‐oxidation; anti‐pigmenting; Female; Glycine - administration & dosage; Glycine - analogs & derivatives; Glycine - pharmacology; Healthy Volunteers; Humans; Male; Melanins - radiation effects; mercaptoniacinamide (2‐MNG); Middle Aged; Skin - drug effects; Skin - metabolism; Skin - radiation effects; Skin Pigmentation - drug effects; Skin Pigmentation - radiation effects; Sunbathing; topical; Ultraviolet Rays - adverse effects; Young Adult; mercaptoniacinamide (2‐MNG); topical; anti‐pigmenting; anti‐oxidation

Background Chronic nonextreme sun exposure induces two mechanisms of skin pigmentation, causing immediate darkening and delayed tanning. A new molecule, 2‐mercaptonicotinoyl glycine (2‐MNG), has been shown in vitro to inhibit both immediate darkening and new melanin synthesis via covalent conjugatio...