RB1 loss induces quiescent state through downregulation of RAS signaling in mammary epithelial cells

• Published in: Cancer science Vol. 115; no. 5; pp. 1576 - 1586
• Main Authors: Gong, Linxiang, Voon, Dominic Chih-Cheng, Nakayama, Joji, Takahashi, Chiaki, Kohno, Susumu
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.05.2024; John Wiley and Sons Inc
• Subjects: Antibodies; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cancer; Cell cycle; Cell Line, Tumor; Cyclin-dependent kinase inhibitor p27; Cyclin-Dependent Kinase Inhibitor p27 - genetics; Cyclin-Dependent Kinase Inhibitor p27 - metabolism; Cyclin-dependent kinases; Cyclins; DNA damage; Down-Regulation; Epithelial cells; Epithelial Cells - metabolism; Epithelial-Mesenchymal Transition - genetics; Farnesyltransferase; Female; Humans; Infections; Kinases; Mammary gland; Mammary Glands, Human - cytology; Mammary Glands, Human - metabolism; Mammary Glands, Human - pathology; MAP kinase; Myc protein; Original; ORIGINAL ARTICLES; Ovaries; Proteins; ras Proteins - genetics; ras Proteins - metabolism; Retinoblastoma; Retinoblastoma Binding Proteins - genetics; Retinoblastoma Binding Proteins - metabolism; Retinoblastoma Protein - genetics; Retinoblastoma Protein - metabolism; Senescence; Signal Transduction; Small cell lung carcinoma; Transcription factors; Tumor suppressor genes; Tumors; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism; RB1; RBL2/p130; quiescence; RAS; MYC

While loss of function (LOF) of retinoblastoma 1 (RB1) tumor suppressor is known to drive initiation of small-cell lung cancer and retinoblastoma, RB1 mutation is rarely observed in breast cancers at their initiation. In this study, we investigated the impact on untransformed mammary epithelial cell...